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- W2008273624 abstract "The caudal-associated homeobox transcription factor, CDX1, performs critical functions in intestinal cell proliferation, differentiation, and neoplasia. In this study, we have identified the molecular mechanism underlying the CDX1-mediated regulation of intestinal cell differentiation. CDX1 enhanced the expression of PPARgamma gene, a master transcriptional regulator of intestinal differentiation, at the transcriptional level, via functional interaction with CCAAT/enhancer-binding protein alpha (C/EBPalpha). Butyrate, an intestinal differentiation inducer, increased the protein interaction of CDX1 and C/EBPalpha, thereby resulting in a significant increase in PPARgamma expression. These results show that the regulation of target gene expression for intestinal determination is dependent on a transcriptional cascade of CDX1, C/EBPalpha, and PPARgamma." @default.
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- W2008273624 date "2008-12-04" @default.
- W2008273624 modified "2023-09-25" @default.
- W2008273624 title "Homeodomain transcription factor CDX1 is required for the transcriptional induction of PPARγ in intestinal cell differentiation" @default.
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- W2008273624 doi "https://doi.org/10.1016/j.febslet.2008.11.030" @default.
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