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- W2008278325 abstract "Detailed cytogenetic and molecular biologic studies have been performed on the human KB tumor cell line and four methotrexate-resistant subclones. Results are presented, demonstrating that the gene encoding the target enzyme dihydrofolate reductase is increasingly amplified in progressively methotrexate-resistant subclones, and that dihydrofolate reductase sequences are localized to a homogeneously staining region on chromosome 10q." @default.
- W2008278325 created "2016-06-24" @default.
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- W2008278325 date "1985-08-01" @default.
- W2008278325 modified "2023-09-26" @default.
- W2008278325 title "Analysis of dihydrofolate reductase gene amplification in a methotrexate-resistant human tumor cell line" @default.
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- W2008278325 doi "https://doi.org/10.1016/0165-4608(85)90112-8" @default.
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