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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008284328> ?p ?o ?g. }

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• W2008284328 abstract "The coordinated action of histone acetyltransferases (HATs) and ATP-dependent chromatin remodeling enzymes in promoter-dependent transcription initiation represents a paradigm for how epigenetic information regulates gene expression. However, little is known about how such enzymes function during transcription elongation. Here, we investigated the role of RSC, a bromodomain-containing ATPase, in nucleosome transcription in vitro. Purified S. cerevisiae RNA polymerase II (Pol II) arrests at two primary locations on a positioned mononucleosome. RSC stimulates passage of Pol II through these sites. The function of RSC in elongation requires the energy of ATP hydrolysis. Moreover, the SAGA and NuA4 HATs strongly stimulated RSC's effect on elongation. The stimulation correlates closely with acetyl-CoA-dependent recruitment of RSC to nucleosomes. Thus, RSC can recognize acetylated nucleosomes and facilitate passage of Pol II through them. These data support the view that histone modifications regulate accessibility of the coding region to Pol II." @default.
• W2008284328 created "2016-06-24" @default.
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• W2008284328 creator A5059586165 @default.
• W2008284328 creator A5083581319 @default.
• W2008284328 date "2006-11-01" @default.
• W2008284328 modified "2023-09-29" @default.
• W2008284328 title "RSC Exploits Histone Acetylation to Abrogate the Nucleosomal Block to RNA Polymerase II Elongation" @default.
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• W2008284328 doi "https://doi.org/10.1016/j.molcel.2006.09.012" @default.
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