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• W2008290417 startingPage "781" @default.
• W2008290417 abstract "The four enantiomeric forms of the triazole plant growth retardant, paclobutrazol, [(2RS, 3RS)-1-(4chlorophenyl)-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)-pentan-3-ol] were tested as inhibitors of cell growth and sterol composition using a celery suspension culture. The (2R,3R)- and (2R,3S)-enantiomers were potent inhibitors of cell growth and caused a large accumulation of the 14α-methylsterols obtusifoliol, cycloeucalenol, 14α,24-dimethylcholest-8-en-3β-ol and 14α,24-dimethylcholesta-8,24(28)-dien-3β-ol. The (2S,3S)- and (2S,3R)-enantiomers on the other hand were only inhibitory to growth and sterol 14α-demethylation at higher concentrations. It is concluded that the (2R)-configuration confers the highest potency both for retarding cell proliferation and for inhibition of the cytochrome P-450 dependent sterol 14α-demethylation reaction in celery cells. A lowering of the stigmasterol: sitosterol ratio was noted, particularly with the (2R,3R)- and (2S,3S)-enantiomers, which suggested that the sterol Δ22-desaturase may also be a target for inhibition by triazoles. The relevance of these results to the mode of action of (2RS,3RS)-paclobutrazol as a plant growth retardant is discussed." @default.
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• W2008290417 date "1989-01-01" @default.
• W2008290417 modified "2023-09-29" @default.
• W2008290417 title "Inhibition of celery cell growth and sterol biosynthesis by the enantiomers of paclobutrazol" @default.
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• W2008290417 doi "https://doi.org/10.1016/0031-9422(89)80115-3" @default.
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