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- W2008292017 abstract "Soon after becoming the Director of the National Institutes of Health (NIH) in May 2002, Elias A. Zerhouni, M.D. convened a series of meetings to chart a “roadmap” for medical research in the 21st century. The purpose was to identify major opportunities and gaps in biomedical research that no single institute at the NIH could tackle alone but that the agency as a whole must address to make the biggest impact on the progress of medical research. Developed with input from meetings with more than 300 nationally recognized leaders in academia, industry, government, and the public, the NIH Roadmap provides a framework of the priorities the NIH as a whole must address in order to optimize its entire research portfolio. It lays out a vision for a more efficient and productive system of medical research. It identifies the most compelling opportunities in three main areas: new pathways to discovery, research teams of the future, and re-engineering the clinical research enterprise.The “New Pathways to Discovery” theme of the NIH Roadmap addresses the need to advance our understanding of the daunting complexity of biological systems. Future progress in medicine will require a quantitative understanding of the many interconnected networks of molecules that comprise our cells and tissues, their interactions, and regulation. There is a need to more precisely know the combination of molecular events that lead to disease to truly revolutionize medicine. New Pathways to Discovery also sets out to build a better “toolbox” for medical research in the 21st century. The implementation plans for this area include biological building blocks, biological pathways, networks, molecular libraries, and molecular imaging, structural biology, bioinformatics, and computational biology and nanomedicine.The “Research Teams of the Future” Roadmap theme was developed because the scale and complexity of today’s biomedical research problems increasingly demand that scientists move beyond the confines of their own discipline and explore new organizational models for team science. For example, imaging research often requires radiologists, physicists, cell biologists, and computer programmers to work together on integrated teams. This NIH Roadmap theme seeks to encourage scientists and scientific institutions to test alternative models for conducting research. Implementation plans in this area include high-risk research, interdisciplinary research, and facilitation of public-private partnerships.The third theme, “Re-engineering the Clinical Research Enterprise,” is intended to address the need of promoting better integration of existing clinical research networks, encouraging the development of technologies to improve the assessment of clinical outcomes, harmonizing regulatory processes, and enhancing training for clinical researchers. A major goal of this initiative is to more fully involve and empower the public in the research process.Interested investigators should see further details describing the development of the Roadmap as well as a continuously updated listing of new initiatives, including RFAs, which can be found at the following website: nihroadmap.nih.gov. Soon after becoming the Director of the National Institutes of Health (NIH) in May 2002, Elias A. Zerhouni, M.D. convened a series of meetings to chart a “roadmap” for medical research in the 21st century. The purpose was to identify major opportunities and gaps in biomedical research that no single institute at the NIH could tackle alone but that the agency as a whole must address to make the biggest impact on the progress of medical research. Developed with input from meetings with more than 300 nationally recognized leaders in academia, industry, government, and the public, the NIH Roadmap provides a framework of the priorities the NIH as a whole must address in order to optimize its entire research portfolio. It lays out a vision for a more efficient and productive system of medical research. It identifies the most compelling opportunities in three main areas: new pathways to discovery, research teams of the future, and re-engineering the clinical research enterprise. The “New Pathways to Discovery” theme of the NIH Roadmap addresses the need to advance our understanding of the daunting complexity of biological systems. Future progress in medicine will require a quantitative understanding of the many interconnected networks of molecules that comprise our cells and tissues, their interactions, and regulation. There is a need to more precisely know the combination of molecular events that lead to disease to truly revolutionize medicine. New Pathways to Discovery also sets out to build a better “toolbox” for medical research in the 21st century. The implementation plans for this area include biological building blocks, biological pathways, networks, molecular libraries, and molecular imaging, structural biology, bioinformatics, and computational biology and nanomedicine. The “Research Teams of the Future” Roadmap theme was developed because the scale and complexity of today’s biomedical research problems increasingly demand that scientists move beyond the confines of their own discipline and explore new organizational models for team science. For example, imaging research often requires radiologists, physicists, cell biologists, and computer programmers to work together on integrated teams. This NIH Roadmap theme seeks to encourage scientists and scientific institutions to test alternative models for conducting research. Implementation plans in this area include high-risk research, interdisciplinary research, and facilitation of public-private partnerships. The third theme, “Re-engineering the Clinical Research Enterprise,” is intended to address the need of promoting better integration of existing clinical research networks, encouraging the development of technologies to improve the assessment of clinical outcomes, harmonizing regulatory processes, and enhancing training for clinical researchers. A major goal of this initiative is to more fully involve and empower the public in the research process. Interested investigators should see further details describing the development of the Roadmap as well as a continuously updated listing of new initiatives, including RFAs, which can be found at the following website: nihroadmap.nih.gov." @default.
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- W2008292017 date "2003-12-01" @default.
- W2008292017 modified "2023-10-14" @default.
- W2008292017 title "This month at the NIH: NIH roadmap: accelerating medical discovery to improve health" @default.
- W2008292017 doi "https://doi.org/10.1053/j.gastro.2003.10.027" @default.
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