Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008306196> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2008306196 endingPage "236" @default.
- W2008306196 startingPage "223" @default.
- W2008306196 abstract "Renal microcirculation and function were studied in the unilateral clamp-induced ischemia/reperfusion model in anesthetized rats. After 60-min reperfusion fluorochrome-labeled globulin was injected i.v. allowing histological determination of capillary plasma flow patterns (CPFP). In the 60-min ischemia protocol the untreated group revealed poor capillary labeling in the outer medulla (OM), whereas cortical perfusion patterns were only slightly altered. Pre- and postischemic treatment with diltiazem led to significant improvement of CPFP in the OM: 4.9% of tissue areas were lying more than 60 μm from the next perfused capillary vs 70.2% after untreated ischemia. Postischemic treatment with diltiazem proved much less effective. Inulin clearance (CIn) amounted to less than 2% of baseline values irrespective of the treatment regimen. However, in the 30-min ischemia protocol, displaying normal CPFP, preservation of CIn was evident and most effective after pre- and postischemic diltiazem treatment (53% vs 8% after untreated ischemia). Measurements of tubular function, however, did not reveal any significant improvement after diltiazem treatment. This observation and the fact that the drug has a vasodilating effect lend support to the view that the preservation of glomerular filtration rate (GFR) is most likely mediated by vascular mechanisms. In conclusion, in this experimental model diltiazem significantly reduced postischemic disturbances of renal microcirculation occurring after prolonged periods of ischemia and was clearly efficient in maintaining GFR after shorter ischemic episodes; however, tubular function was not preserved. Our results, as well as those of other authors, strongly suggest that diltiazem causes the aforementioned effects mainly by actions at the vascular site." @default.
- W2008306196 created "2016-06-24" @default.
- W2008306196 creator A5038141123 @default.
- W2008306196 creator A5050129927 @default.
- W2008306196 creator A5056391677 @default.
- W2008306196 creator A5072407971 @default.
- W2008306196 date "1989-11-01" @default.
- W2008306196 modified "2023-09-27" @default.
- W2008306196 title "Influence of diltiazem on postischemic microcirculation and function in the rat kidney" @default.
- W2008306196 cites W14681177 @default.
- W2008306196 cites W1508737915 @default.
- W2008306196 cites W1882830153 @default.
- W2008306196 cites W1965718061 @default.
- W2008306196 cites W1968209789 @default.
- W2008306196 cites W1972360041 @default.
- W2008306196 cites W1978447348 @default.
- W2008306196 cites W1989836067 @default.
- W2008306196 cites W1999679522 @default.
- W2008306196 cites W2026441879 @default.
- W2008306196 cites W2038481143 @default.
- W2008306196 cites W2067768668 @default.
- W2008306196 cites W2094729588 @default.
- W2008306196 cites W2127102931 @default.
- W2008306196 cites W2320046967 @default.
- W2008306196 cites W2340075501 @default.
- W2008306196 cites W2404632594 @default.
- W2008306196 cites W2406662705 @default.
- W2008306196 cites W2416575187 @default.
- W2008306196 cites W2466926886 @default.
- W2008306196 cites W2468073229 @default.
- W2008306196 cites W2615628794 @default.
- W2008306196 cites W597378496 @default.
- W2008306196 doi "https://doi.org/10.1016/0026-2862(89)90001-0" @default.
- W2008306196 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2607995" @default.
- W2008306196 hasPublicationYear "1989" @default.
- W2008306196 type Work @default.
- W2008306196 sameAs 2008306196 @default.
- W2008306196 citedByCount "3" @default.
- W2008306196 crossrefType "journal-article" @default.
- W2008306196 hasAuthorship W2008306196A5038141123 @default.
- W2008306196 hasAuthorship W2008306196A5050129927 @default.
- W2008306196 hasAuthorship W2008306196A5056391677 @default.
- W2008306196 hasAuthorship W2008306196A5072407971 @default.
- W2008306196 hasConcept C120770815 @default.
- W2008306196 hasConcept C126322002 @default.
- W2008306196 hasConcept C126894567 @default.
- W2008306196 hasConcept C12722491 @default.
- W2008306196 hasConcept C134018914 @default.
- W2008306196 hasConcept C146957229 @default.
- W2008306196 hasConcept C159641895 @default.
- W2008306196 hasConcept C164705383 @default.
- W2008306196 hasConcept C2776741139 @default.
- W2008306196 hasConcept C2780091579 @default.
- W2008306196 hasConcept C42219234 @default.
- W2008306196 hasConcept C519063684 @default.
- W2008306196 hasConcept C541997718 @default.
- W2008306196 hasConcept C71924100 @default.
- W2008306196 hasConceptScore W2008306196C120770815 @default.
- W2008306196 hasConceptScore W2008306196C126322002 @default.
- W2008306196 hasConceptScore W2008306196C126894567 @default.
- W2008306196 hasConceptScore W2008306196C12722491 @default.
- W2008306196 hasConceptScore W2008306196C134018914 @default.
- W2008306196 hasConceptScore W2008306196C146957229 @default.
- W2008306196 hasConceptScore W2008306196C159641895 @default.
- W2008306196 hasConceptScore W2008306196C164705383 @default.
- W2008306196 hasConceptScore W2008306196C2776741139 @default.
- W2008306196 hasConceptScore W2008306196C2780091579 @default.
- W2008306196 hasConceptScore W2008306196C42219234 @default.
- W2008306196 hasConceptScore W2008306196C519063684 @default.
- W2008306196 hasConceptScore W2008306196C541997718 @default.
- W2008306196 hasConceptScore W2008306196C71924100 @default.
- W2008306196 hasIssue "3" @default.
- W2008306196 hasLocation W20083061961 @default.
- W2008306196 hasLocation W20083061962 @default.
- W2008306196 hasOpenAccess W2008306196 @default.
- W2008306196 hasPrimaryLocation W20083061961 @default.
- W2008306196 hasRelatedWork W2008306196 @default.
- W2008306196 hasRelatedWork W2042033030 @default.
- W2008306196 hasRelatedWork W2048039626 @default.
- W2008306196 hasRelatedWork W2070511355 @default.
- W2008306196 hasRelatedWork W2082456910 @default.
- W2008306196 hasRelatedWork W2098742882 @default.
- W2008306196 hasRelatedWork W2127085070 @default.
- W2008306196 hasRelatedWork W2319873196 @default.
- W2008306196 hasRelatedWork W2400445066 @default.
- W2008306196 hasRelatedWork W2042893290 @default.
- W2008306196 hasVolume "38" @default.
- W2008306196 isParatext "false" @default.
- W2008306196 isRetracted "false" @default.
- W2008306196 magId "2008306196" @default.
- W2008306196 workType "article" @default.