FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008307521> ?p ?o ?g. }

• W2008307521 endingPage "10232" @default.
• W2008307521 startingPage "10227" @default.
• W2008307521 abstract "The deamidation of asparagine (Asn) residues is the most common type of spontaneous post-translational protein modification and plays a vital role in inflammation, protein transformation, apoptosis, aging, and a number of degenerative diseases. Here we present a full molecular description of asparagine deamidation in the Na+(Asn) complex by studying its collision-induced dissociation (CID) with Xe using a guided ion beam tandem mass spectrometer (GIBMS). Advanced methods for analysis of the energy-dependent CID cross section, considering both competing and sequential processes, provide the 0 K barrier for deamidation after accounting for unimolecular decay rates, internal energy of reactant ions, and multiple ion-neutral collisions. Relaxed potential energy surface scans performed at the B3LYP/6-31G(d) level identify the transition state (TS) and intermediate reaction species for Na+(Asn) deamidation, structures that are further optimized at the B3LYP/6-311+G(d,p) level. Single-point energies of the key optimized structures are calculated at MP2(full), B3LYP, and B3P86 levels using a 6-311+G(2d,2p) basis set. This coordinated application of both experimental work and quantum chemical calculations allows for a complete characterization of the elementary steps of this reaction and identification of the rate-limiting elementary step of Asn deamidation. The latter is measured to require 1.61 ± 0.08 eV and involves formation of a cyclic succinic ring structure." @default.
• W2008307521 created "2016-06-24" @default.
• W2008307521 creator A5054043909 @default.
• W2008307521 creator A5073336335 @default.
• W2008307521 date "2008-07-10" @default.
• W2008307521 modified "2023-09-26" @default.
• W2008307521 title "Thermodynamics and Mechanism of the Deamidation of Sodium-Bound Asparagine" @default.
• W2008307521 cites W1971970279 @default.
• W2008307521 cites W1979410678 @default.
• W2008307521 cites W1982249962 @default.
• W2008307521 cites W1991662337 @default.
• W2008307521 cites W1993797810 @default.
• W2008307521 cites W1995533954 @default.
• W2008307521 cites W2006141434 @default.
• W2008307521 cites W2015174108 @default.
• W2008307521 cites W20202613 @default.
• W2008307521 cites W2020418396 @default.
• W2008307521 cites W2021094219 @default.
• W2008307521 cites W2021660561 @default.
• W2008307521 cites W2025773262 @default.
• W2008307521 cites W2027965396 @default.
• W2008307521 cites W2035594922 @default.
• W2008307521 cites W2045796411 @default.
• W2008307521 cites W2053223828 @default.
• W2008307521 cites W2057787908 @default.
• W2008307521 cites W2058175061 @default.
• W2008307521 cites W2063572669 @default.
• W2008307521 cites W2065709175 @default.
• W2008307521 cites W2066144076 @default.
• W2008307521 cites W2066365157 @default.
• W2008307521 cites W2077731186 @default.
• W2008307521 cites W2078843151 @default.
• W2008307521 cites W2084528818 @default.
• W2008307521 cites W2085514791 @default.
• W2008307521 cites W2086505034 @default.
• W2008307521 cites W2148941593 @default.
• W2008307521 cites W2160736598 @default.
• W2008307521 cites W2165987614 @default.
• W2008307521 cites W2169988510 @default.
• W2008307521 cites W42925865 @default.
• W2008307521 doi "https://doi.org/10.1021/ja801726g" @default.
• W2008307521 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18613670" @default.
• W2008307521 hasPublicationYear "2008" @default.
• W2008307521 type Work @default.
• W2008307521 sameAs 2008307521 @default.
• W2008307521 citedByCount "37" @default.
• W2008307521 countsByYear W20083075212014 @default.
• W2008307521 countsByYear W20083075212016 @default.
• W2008307521 countsByYear W20083075212017 @default.
• W2008307521 countsByYear W20083075212018 @default.
• W2008307521 countsByYear W20083075212019 @default.
• W2008307521 countsByYear W20083075212020 @default.
• W2008307521 countsByYear W20083075212021 @default.
• W2008307521 countsByYear W20083075212022 @default.
• W2008307521 crossrefType "journal-article" @default.
• W2008307521 hasAuthorship W2008307521A5054043909 @default.
• W2008307521 hasAuthorship W2008307521A5073336335 @default.
• W2008307521 hasConcept C102931765 @default.
• W2008307521 hasConcept C125277925 @default.
• W2008307521 hasConcept C145148216 @default.
• W2008307521 hasConcept C147597530 @default.
• W2008307521 hasConcept C147789679 @default.
• W2008307521 hasConcept C162356407 @default.
• W2008307521 hasConcept C178790620 @default.
• W2008307521 hasConcept C181199279 @default.
• W2008307521 hasConcept C185592680 @default.
• W2008307521 hasConcept C2775895851 @default.
• W2008307521 hasConcept C2780784506 @default.
• W2008307521 hasConcept C31827203 @default.
• W2008307521 hasConcept C32909587 @default.
• W2008307521 hasConcept C43617362 @default.
• W2008307521 hasConcept C515207424 @default.
• W2008307521 hasConcept C55493867 @default.
• W2008307521 hasConceptScore W2008307521C102931765 @default.
• W2008307521 hasConceptScore W2008307521C125277925 @default.
• W2008307521 hasConceptScore W2008307521C145148216 @default.
• W2008307521 hasConceptScore W2008307521C147597530 @default.
• W2008307521 hasConceptScore W2008307521C147789679 @default.
• W2008307521 hasConceptScore W2008307521C162356407 @default.
• W2008307521 hasConceptScore W2008307521C178790620 @default.
• W2008307521 hasConceptScore W2008307521C181199279 @default.
• W2008307521 hasConceptScore W2008307521C185592680 @default.
• W2008307521 hasConceptScore W2008307521C2775895851 @default.
• W2008307521 hasConceptScore W2008307521C2780784506 @default.
• W2008307521 hasConceptScore W2008307521C31827203 @default.
• W2008307521 hasConceptScore W2008307521C32909587 @default.
• W2008307521 hasConceptScore W2008307521C43617362 @default.
• W2008307521 hasConceptScore W2008307521C515207424 @default.
• W2008307521 hasConceptScore W2008307521C55493867 @default.
• W2008307521 hasIssue "31" @default.
• W2008307521 hasLocation W20083075211 @default.
• W2008307521 hasLocation W20083075212 @default.
• W2008307521 hasOpenAccess W2008307521 @default.
• W2008307521 hasPrimaryLocation W20083075211 @default.
• W2008307521 hasRelatedWork W1966741770 @default.
• W2008307521 hasRelatedWork W1971682310 @default.
• W2008307521 hasRelatedWork W2018957170 @default.
• W2008307521 hasRelatedWork W2063901157 @default.

• next