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- W2008314305 abstract "Cohn fraction III-O of human plasma proteins has previously been shown to contain a peptide which produces vasodilator responses in intact vascular beds. This peptide has bradykinin-like pharmacological actions but it can be distinguished from bradykinin. A process of serial fractionation of Cohn fraction III-O on Sephadex CM-25 and G-25 gels, followed by ion exchange chromatography with gradient elution on a Bio-Rex 70 column and subsequent desalting has permitted purification of this peptide. Amino acid analysis suggested a peptide with 14 amino acyl-residues and a calculated molecular weight of 1,780. The purified material retained the vasodilator properties of impure sources of the peptide, but was highly unstable. There was no interaction with anti-bradykinin antibodies." @default.
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- W2008314305 date "1980-05-01" @default.
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- W2008314305 title "Purification of a Peptide with Venoconstrictor and Vasodepressor Activity, from Cohn Fraction III-O of Human Plasma Protein" @default.
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- W2008314305 doi "https://doi.org/10.1111/j.1423-0410.1980.tb02365.x" @default.
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