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• W2008315802 abstract "In an effort to better understand the antiproliferative effects of the tridentate hydrazone chelators di-2-pyridyl ketone isonicotinoyl hydrazone (HPKIH) and di-2-pyridyl ketone benzoyl hydrazone (HPKBH), we report the coordination chemistry of these ligands with the divalent metal ions, Mn, Co, Ni, Cu, and Zn. These complexes are compared with their FeII analogues which were reported previously. The crystal structures of Co(PKIH)2, Ni(PKIH)2, Cu(PKIH)2, Mn(PKBH)2, Ni(PKBH)2, Cu(PKBH)2, and Zn(PKBH)2 are reported where similar bis-tridenate coordination modes of the ligands are defined. In pure DMF, all complexes except the ZnII compounds exhibit metal-centered MIII/II (Mn, Fe, Co, Ni) or MII/I (Cu) redox processes. All complexes show ligand-centered reductions at low potential. Electrochemistry in a mixed water/DMF solvent only elicited metal-centered responses from the Co and Fe complexes. Remarkably, all complexes show antiproliferative activity against the SK-N-MC neuroepithelioma cell line similar to (HPKIH) or significantly greater than that of the (HPKBH) ligand which suggests a mechanism that does not only involve the redox activity of these complexes. In fact, we suggest that the complexes act as lipophilic transport shuttles that allow entrance to the cell and enable the delivery of both the ligand and metal which act in concert to inhibit proliferation." @default.
• W2008315802 created "2016-06-24" @default.
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• W2008315802 date "2005-12-08" @default.
• W2008315802 modified "2023-10-03" @default.
• W2008315802 title "Complexes of Cytotoxic Chelators from the Dipyridyl Ketone Isonicotinoyl Hydrazone (HPKIH) Analogues" @default.
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• W2008315802 doi "https://doi.org/10.1021/ic051573l" @default.
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