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- W2008320608 abstract "P2X7 receptors trigger Ca2+-dependent exocytotic glutamate release, but also function as a route for non-exocytotic glutamate release from neurons or astrocytes. To gain an insight into the mechanisms involving the P2X7 receptor as a direct pathway for glutamate release, we compared the behavior of a full-length rat P2X7 receptor, a truncated rat P2X7 receptor in which the carboxyl tail had been deleted, a rat P2X7 receptor with the 18-amino acid cysteine-rich motif of the carboxyl tail deleted, and a rat P2X2 receptor, all of which are expressed in HEK293 cells. We found that the P2X7 receptor function as a route for glutamate release was antagonized in a non-competitive way by extracellular Mg2+, did not require the recruitment of pore-forming molecules, and was dependent on the carboxyl tail. Indeed, the truncated P2X7 receptor and the P2X7 receptor with the deleted cysteine-rich motif both lost their function as a pathway for glutamate release, while still evoking intracellular Ca2+ elevation. No glutamate efflux was observed through the P2X2 receptor. Notably, HEK293 cells (lacking the machinery for Ca2+-dependent exocytosis), when transfected with P2X7 receptors, appear to be a suitable model for investigating the P2X7 receptor as a route for non-exocytotic glutamate efflux." @default.
- W2008320608 created "2016-06-24" @default.
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- W2008320608 date "2013-02-03" @default.
- W2008320608 modified "2023-09-23" @default.
- W2008320608 title "The P2X7 receptor as a route for non-exocytotic glutamate release: dependence on the carboxyl tail" @default.
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- W2008320608 cites W1574063361 @default.
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- W2008320608 cites W1620679902 @default.
- W2008320608 cites W1824528611 @default.
- W2008320608 cites W1899748273 @default.
- W2008320608 cites W1902132075 @default.
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- W2008320608 cites W1972892494 @default.
- W2008320608 cites W1976824217 @default.
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- W2008320608 cites W1995622771 @default.
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- W2008320608 cites W2001741536 @default.
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- W2008320608 cites W2025990788 @default.
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- W2008320608 cites W2063771518 @default.
- W2008320608 cites W2066784771 @default.
- W2008320608 cites W2068517470 @default.
- W2008320608 cites W2068606587 @default.
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- W2008320608 cites W2072214489 @default.
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- W2008320608 cites W2148856791 @default.
- W2008320608 cites W2152089134 @default.
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- W2008320608 doi "https://doi.org/10.1111/jnc.12143" @default.
- W2008320608 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23293841" @default.
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