FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008333413> ?p ?o ?g. }

• W2008333413 endingPage "1707" @default.
• W2008333413 startingPage "1704" @default.
• W2008333413 abstract "Objective: Sporadic late-onset medullary carcinoma of the thyroid is quite rare. Usually, the patient presents with a thyroid mass or neck node metastasis along with high levels of calcitonin and preoperative fine needle aspiration biopsy suggestive of medullary carcinoma of the thyroid. The role of genetic testing in such individuals, along with testing of other family members, remains somewhat unclear at this stage, especially in patients presenting with familial medullary thyroid carcinoma. Genetic testing with RET proto-oncogene mutational studies is very popular in familial medullary thyroid carcinoma, especially in children, with routine prophylactic thyroidectomy. However, its indications in adults remain unclear at this time. Case Study: Recently, a 69-year-old woman presented with a thyroid mass and underwent total thyroidectomy and central compartment dissection. She was found to have medullary carcinoma of the thyroid. The patient had four children, three of whom were found to have a RET mutation similar to their mother's, V804M. In view of the RET mutation, the three children were offered prophylactic thyroidectomy at ages 42, 45, and 47. The patient's son was noted to have extensive C-cell hyperplasia in both lobes of the thyroid. The other two individuals had benign pathology with no evidence of C-cell hyperplasia. Conclusions: There is no definite consensus of opinion about the need for prophylactic total thyroidectomy in adults with RET mutation. The rarely reported 804 mutation is, however, a predictor of medullary carcinoma of the thyroid. One individual in this group had extensive C-cell hyperplasia, suggesting that he would have developed medullary carcinoma of the thyroid in the future. Prophylactic thyroidectomy should be recommended in patients with RET mutation and a family history of medullary carcinoma of the thyroid; however, its role in adult family members needs to be evaluated with larger registry of prophylactic thyroidectomy. Whether these adults with rare 804-mutation could be observed and followed with serial calcitonin, ultrasound, or calcitonin stimulation tests remains to be studied." @default.
• W2008333413 created "2016-06-24" @default.
• W2008333413 creator A5009898984 @default.
• W2008333413 creator A5042607297 @default.
• W2008333413 creator A5067558108 @default.
• W2008333413 creator A5087689377 @default.
• W2008333413 date "2006-09-01" @default.
• W2008333413 modified "2023-10-18" @default.
• W2008333413 title "Late-Onset Medullary Carcinoma of the Thyroid: Need for Genetic Testing and Prophylactic Thyroidectomy in Adult Family Members" @default.
• W2008333413 cites W1969482148 @default.
• W2008333413 cites W1986046190 @default.
• W2008333413 cites W1990196512 @default.
• W2008333413 cites W2014950391 @default.
• W2008333413 cites W2055996224 @default.
• W2008333413 cites W2066287388 @default.
• W2008333413 cites W2076580215 @default.
• W2008333413 cites W2114578972 @default.
• W2008333413 cites W2125695627 @default.
• W2008333413 cites W2128805986 @default.
• W2008333413 cites W2139925475 @default.
• W2008333413 cites W2144960699 @default.
• W2008333413 cites W2156734853 @default.
• W2008333413 cites W2416085998 @default.
• W2008333413 cites W4248988283 @default.
• W2008333413 doi "https://doi.org/10.1097/01.mlg.0000233509.83679.ee" @default.
• W2008333413 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16955009" @default.
• W2008333413 hasPublicationYear "2006" @default.
• W2008333413 type Work @default.
• W2008333413 sameAs 2008333413 @default.
• W2008333413 citedByCount "16" @default.
• W2008333413 countsByYear W20083334132012 @default.
• W2008333413 countsByYear W20083334132014 @default.
• W2008333413 countsByYear W20083334132015 @default.
• W2008333413 countsByYear W20083334132016 @default.
• W2008333413 countsByYear W20083334132018 @default.
• W2008333413 countsByYear W20083334132021 @default.
• W2008333413 crossrefType "journal-article" @default.
• W2008333413 hasAuthorship W2008333413A5009898984 @default.
• W2008333413 hasAuthorship W2008333413A5042607297 @default.
• W2008333413 hasAuthorship W2008333413A5067558108 @default.
• W2008333413 hasAuthorship W2008333413A5087689377 @default.
• W2008333413 hasConcept C126322002 @default.
• W2008333413 hasConcept C142724271 @default.
• W2008333413 hasConcept C195121873 @default.
• W2008333413 hasConcept C2776667971 @default.
• W2008333413 hasConcept C2777074255 @default.
• W2008333413 hasConcept C2777546739 @default.
• W2008333413 hasConcept C2778474501 @default.
• W2008333413 hasConcept C2779627488 @default.
• W2008333413 hasConcept C2780673598 @default.
• W2008333413 hasConcept C2993294228 @default.
• W2008333413 hasConcept C526584372 @default.
• W2008333413 hasConcept C71924100 @default.
• W2008333413 hasConceptScore W2008333413C126322002 @default.
• W2008333413 hasConceptScore W2008333413C142724271 @default.
• W2008333413 hasConceptScore W2008333413C195121873 @default.
• W2008333413 hasConceptScore W2008333413C2776667971 @default.
• W2008333413 hasConceptScore W2008333413C2777074255 @default.
• W2008333413 hasConceptScore W2008333413C2777546739 @default.
• W2008333413 hasConceptScore W2008333413C2778474501 @default.
• W2008333413 hasConceptScore W2008333413C2779627488 @default.
• W2008333413 hasConceptScore W2008333413C2780673598 @default.
• W2008333413 hasConceptScore W2008333413C2993294228 @default.
• W2008333413 hasConceptScore W2008333413C526584372 @default.
• W2008333413 hasConceptScore W2008333413C71924100 @default.
• W2008333413 hasIssue "9" @default.
• W2008333413 hasLocation W20083334131 @default.
• W2008333413 hasLocation W20083334132 @default.
• W2008333413 hasOpenAccess W2008333413 @default.
• W2008333413 hasPrimaryLocation W20083334131 @default.
• W2008333413 hasRelatedWork W1964021982 @default.
• W2008333413 hasRelatedWork W2016726024 @default.
• W2008333413 hasRelatedWork W2024569254 @default.
• W2008333413 hasRelatedWork W2064699051 @default.
• W2008333413 hasRelatedWork W2095822679 @default.
• W2008333413 hasRelatedWork W2395722606 @default.
• W2008333413 hasRelatedWork W2564955176 @default.
• W2008333413 hasRelatedWork W2885222118 @default.
• W2008333413 hasRelatedWork W3025445135 @default.
• W2008333413 hasRelatedWork W4251208882 @default.
• W2008333413 hasVolume "116" @default.
• W2008333413 isParatext "false" @default.
• W2008333413 isRetracted "false" @default.
• W2008333413 magId "2008333413" @default.
• W2008333413 workType "article" @default.