Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008335345> ?p ?o ?g. }
- W2008335345 endingPage "80" @default.
- W2008335345 startingPage "70" @default.
- W2008335345 abstract "Trefoil factors (TFFs) are secreted gastrointestinal proteins that have been shown to protect and promote healing of the gastrointestinal tract. Moreover, pS2/TFF1 is essential for normal differentiation of the gastric mucosa because deficient mice develop antropyloric adenomas. To date, it is unclear how TFFs mediate their functions.Using the yeast 2-hybrid system, we attempted to identify murine TFF1 interacting proteins by screening a stomach and duodenum complementary DNA (cDNA) expression library.Four positive clones were isolated. Sequence and expression studies showed that they corresponded to the murine counterpart of human cDNA sequences encoding carboxy-terminal fragments of mMuc2 (489 residues) and mMuc5AC (427, 430, and 894 residues) mucin proteins. Mutagenesis experiments showed that TFF1 interacts with the 2 mucins through binding with their VWFC1 and VWFC2 (von Willebrand factor C) cysteine-rich domains.These results show that the gastrointestinal protective effect of TFF1, and presumably of the other TFFs, is caused at least partially by their participation, via mucin binding, in the correct organization of the mucous layer that protects the apical side of the mucosa from deleterious luminal agents." @default.
- W2008335345 created "2016-06-24" @default.
- W2008335345 creator A5012068944 @default.
- W2008335345 creator A5021887762 @default.
- W2008335345 creator A5043384190 @default.
- W2008335345 creator A5044788524 @default.
- W2008335345 creator A5053473058 @default.
- W2008335345 creator A5055345137 @default.
- W2008335345 creator A5058304156 @default.
- W2008335345 date "2000-01-01" @default.
- W2008335345 modified "2023-10-18" @default.
- W2008335345 title "pS2/TFF1 interacts directly with the VWFC cysteine-rich domains of mucins" @default.
- W2008335345 cites W1492833857 @default.
- W2008335345 cites W1546825042 @default.
- W2008335345 cites W1562448272 @default.
- W2008335345 cites W1586051439 @default.
- W2008335345 cites W1595402802 @default.
- W2008335345 cites W1617102100 @default.
- W2008335345 cites W166852803 @default.
- W2008335345 cites W1826845578 @default.
- W2008335345 cites W1928894857 @default.
- W2008335345 cites W1963832148 @default.
- W2008335345 cites W1965796742 @default.
- W2008335345 cites W1967130431 @default.
- W2008335345 cites W1968598371 @default.
- W2008335345 cites W1969477102 @default.
- W2008335345 cites W1976162686 @default.
- W2008335345 cites W1981327571 @default.
- W2008335345 cites W1982282184 @default.
- W2008335345 cites W1983854701 @default.
- W2008335345 cites W1991856646 @default.
- W2008335345 cites W1992416270 @default.
- W2008335345 cites W1999512677 @default.
- W2008335345 cites W1999738788 @default.
- W2008335345 cites W2017761896 @default.
- W2008335345 cites W2018579779 @default.
- W2008335345 cites W2025890252 @default.
- W2008335345 cites W2034687052 @default.
- W2008335345 cites W2043836701 @default.
- W2008335345 cites W2044319171 @default.
- W2008335345 cites W2047615179 @default.
- W2008335345 cites W2049898542 @default.
- W2008335345 cites W2049957387 @default.
- W2008335345 cites W2054642708 @default.
- W2008335345 cites W2060513558 @default.
- W2008335345 cites W2061609581 @default.
- W2008335345 cites W2061766612 @default.
- W2008335345 cites W2066696278 @default.
- W2008335345 cites W2066825378 @default.
- W2008335345 cites W2068897525 @default.
- W2008335345 cites W2078213749 @default.
- W2008335345 cites W2091109777 @default.
- W2008335345 cites W2097702986 @default.
- W2008335345 cites W2099770647 @default.
- W2008335345 cites W2117503988 @default.
- W2008335345 cites W2121889529 @default.
- W2008335345 cites W2122849750 @default.
- W2008335345 cites W2123245018 @default.
- W2008335345 cites W2127204678 @default.
- W2008335345 cites W2132932170 @default.
- W2008335345 cites W2135169290 @default.
- W2008335345 cites W2141915473 @default.
- W2008335345 cites W2152345385 @default.
- W2008335345 cites W2164901517 @default.
- W2008335345 cites W2189565186 @default.
- W2008335345 cites W2339420589 @default.
- W2008335345 cites W2888511473 @default.
- W2008335345 cites W4243638039 @default.
- W2008335345 doi "https://doi.org/10.1016/s0016-5085(00)70415-x" @default.
- W2008335345 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10611155" @default.
- W2008335345 hasPublicationYear "2000" @default.
- W2008335345 type Work @default.
- W2008335345 sameAs 2008335345 @default.
- W2008335345 citedByCount "172" @default.
- W2008335345 countsByYear W20083353452012 @default.
- W2008335345 countsByYear W20083353452013 @default.
- W2008335345 countsByYear W20083353452014 @default.
- W2008335345 countsByYear W20083353452015 @default.
- W2008335345 countsByYear W20083353452016 @default.
- W2008335345 countsByYear W20083353452017 @default.
- W2008335345 countsByYear W20083353452018 @default.
- W2008335345 countsByYear W20083353452019 @default.
- W2008335345 countsByYear W20083353452020 @default.
- W2008335345 countsByYear W20083353452021 @default.
- W2008335345 countsByYear W20083353452022 @default.
- W2008335345 countsByYear W20083353452023 @default.
- W2008335345 crossrefType "journal-article" @default.
- W2008335345 hasAuthorship W2008335345A5012068944 @default.
- W2008335345 hasAuthorship W2008335345A5021887762 @default.
- W2008335345 hasAuthorship W2008335345A5043384190 @default.
- W2008335345 hasAuthorship W2008335345A5044788524 @default.
- W2008335345 hasAuthorship W2008335345A5053473058 @default.
- W2008335345 hasAuthorship W2008335345A5055345137 @default.
- W2008335345 hasAuthorship W2008335345A5058304156 @default.
- W2008335345 hasConcept C104317684 @default.
- W2008335345 hasConcept C153911025 @default.
- W2008335345 hasConcept C16318435 @default.
- W2008335345 hasConcept C179264091 @default.