FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008338411> ?p ?o ?g. }

• W2008338411 endingPage "34" @default.
• W2008338411 startingPage "24" @default.
• W2008338411 abstract "Recent evidence from our laboratory has demonstrated that NK/LAK cell activation of human lymphocytes is protein kinase C (PKC)-dependent. Here, we have investigated the translocation of PKC in human NK cells exposed to sensitive targets or to PMA, a phorbol ester. In NK cells exposed to K562 for 6 hr, we observed a weak translocation of PKC whereas in NK cells exposed to PMA more than 90% of cytosolic PKC was translocated to the membrane in less than 5 min. Stimulation of NK cells with an NK-resistant target, however, did not translocate PKC even after 6 hr. Translocation of PKC to the membrane was followed by the appearance of PKM, the cytosolic calcium/phospholipid (Ca2+PL)-independent form of PKC. The conversion of PKC to PKM was mediated by calpain, an intracellular calcium-dependent thiol proteinase. When we used two inhibitors of calpain, calpain inhibitor I (CI-I) and calpain inhibitor II (CI-II), both caused a dose-related enhancement of NK-CMC when the inhibitors were present throughout the 3-hr chromium release assay. This enhancement could be circumvented by PMA or by the PKC inhibitor H-7. CI-I and CI-II added together caused a greater increase in NK-CMC than when each was added alone. CI-I and CI-II also enhanced antibody-dependent cell-mediated cytotoxicity (ADCC), substantiating further our previous contention that the activation of both NK-CMC and ADCC may involve a common lytic pathway. Activation of NK cells with IL-2 for 18 hr at 37 °C was inhibited in the presence of CI-I. To investigate a possible feedback inhibition mechanism due to the buildup of PKC, we examined phosphatidylinositol (PI) metabolism in NK cells activated by IL-2 in either the presence or the absence of CI-I. We observed a significant decrease in PI turnover when NK cells, activated in the presence of IL-2 and CI-I, were stimulated with K562 as compared to NK cells activated by IL-2 alone, then stimulated with K562." @default.
• W2008338411 created "2016-06-24" @default.
• W2008338411 creator A5019861806 @default.
• W2008338411 creator A5041522628 @default.
• W2008338411 date "1991-11-01" @default.
• W2008338411 modified "2023-10-11" @default.
• W2008338411 title "Inhibition of the calpain-mediated proteolysis of protein kinase C enhances lytic activity in human NK cells" @default.
• W2008338411 cites W1481123143 @default.
• W2008338411 cites W1485870594 @default.
• W2008338411 cites W1486602990 @default.
• W2008338411 cites W1491958169 @default.
• W2008338411 cites W1502994709 @default.
• W2008338411 cites W1516085090 @default.
• W2008338411 cites W1558018395 @default.
• W2008338411 cites W1587762077 @default.
• W2008338411 cites W1600999416 @default.
• W2008338411 cites W1615050047 @default.
• W2008338411 cites W1617995910 @default.
• W2008338411 cites W1664582989 @default.
• W2008338411 cites W1817069312 @default.
• W2008338411 cites W1964839077 @default.
• W2008338411 cites W1965150386 @default.
• W2008338411 cites W1973005880 @default.
• W2008338411 cites W1979343444 @default.
• W2008338411 cites W1987722323 @default.
• W2008338411 cites W1996626314 @default.
• W2008338411 cites W2021579201 @default.
• W2008338411 cites W2044129057 @default.
• W2008338411 cites W2048867915 @default.
• W2008338411 cites W2054585569 @default.
• W2008338411 cites W2068877244 @default.
• W2008338411 cites W2093118389 @default.
• W2008338411 cites W2100837269 @default.
• W2008338411 cites W2120553565 @default.
• W2008338411 cites W2136189765 @default.
• W2008338411 cites W2142301692 @default.
• W2008338411 cites W2174520807 @default.
• W2008338411 cites W2221376210 @default.
• W2008338411 cites W4239139991 @default.
• W2008338411 doi "https://doi.org/10.1016/0008-8749(91)90129-y" @default.
• W2008338411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1913839" @default.
• W2008338411 hasPublicationYear "1991" @default.
• W2008338411 type Work @default.
• W2008338411 sameAs 2008338411 @default.
• W2008338411 citedByCount "21" @default.
• W2008338411 countsByYear W20083384112017 @default.
• W2008338411 countsByYear W20083384112019 @default.
• W2008338411 countsByYear W20083384112021 @default.
• W2008338411 countsByYear W20083384112022 @default.
• W2008338411 crossrefType "journal-article" @default.
• W2008338411 hasAuthorship W2008338411A5019861806 @default.
• W2008338411 hasAuthorship W2008338411A5041522628 @default.
• W2008338411 hasConcept C109316439 @default.
• W2008338411 hasConcept C153911025 @default.
• W2008338411 hasConcept C181199279 @default.
• W2008338411 hasConcept C182615771 @default.
• W2008338411 hasConcept C184235292 @default.
• W2008338411 hasConcept C195794163 @default.
• W2008338411 hasConcept C202751555 @default.
• W2008338411 hasConcept C203014093 @default.
• W2008338411 hasConcept C2522874641 @default.
• W2008338411 hasConcept C40677261 @default.
• W2008338411 hasConcept C55493867 @default.
• W2008338411 hasConcept C56928146 @default.
• W2008338411 hasConcept C86803240 @default.
• W2008338411 hasConcept C95444343 @default.
• W2008338411 hasConcept C98539663 @default.
• W2008338411 hasConceptScore W2008338411C109316439 @default.
• W2008338411 hasConceptScore W2008338411C153911025 @default.
• W2008338411 hasConceptScore W2008338411C181199279 @default.
• W2008338411 hasConceptScore W2008338411C182615771 @default.
• W2008338411 hasConceptScore W2008338411C184235292 @default.
• W2008338411 hasConceptScore W2008338411C195794163 @default.
• W2008338411 hasConceptScore W2008338411C202751555 @default.
• W2008338411 hasConceptScore W2008338411C203014093 @default.
• W2008338411 hasConceptScore W2008338411C2522874641 @default.
• W2008338411 hasConceptScore W2008338411C40677261 @default.
• W2008338411 hasConceptScore W2008338411C55493867 @default.
• W2008338411 hasConceptScore W2008338411C56928146 @default.
• W2008338411 hasConceptScore W2008338411C86803240 @default.
• W2008338411 hasConceptScore W2008338411C95444343 @default.
• W2008338411 hasConceptScore W2008338411C98539663 @default.
• W2008338411 hasIssue "1" @default.
• W2008338411 hasLocation W20083384111 @default.
• W2008338411 hasLocation W20083384112 @default.
• W2008338411 hasOpenAccess W2008338411 @default.
• W2008338411 hasPrimaryLocation W20083384111 @default.
• W2008338411 hasRelatedWork W2021039830 @default.
• W2008338411 hasRelatedWork W2021484614 @default.
• W2008338411 hasRelatedWork W2035753258 @default.
• W2008338411 hasRelatedWork W2043941577 @default.
• W2008338411 hasRelatedWork W2044157128 @default.
• W2008338411 hasRelatedWork W2079167666 @default.
• W2008338411 hasRelatedWork W2089163673 @default.
• W2008338411 hasRelatedWork W2151632397 @default.
• W2008338411 hasRelatedWork W2373466283 @default.
• W2008338411 hasRelatedWork W2624521026 @default.
• W2008338411 hasVolume "138" @default.

• next