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- W2008340920 abstract "Tcell antigen receptor (TcR) heterodimers of both the Ti-αβ and Ti-γδ types are expressed at the surface of T cells noncovalently associated with the CD3 complex composed of the monomorphic chains γ, δ, ε and ξ. The structural relationship and assembly of the various components of this multimeric protein complex is still not fully understood. In this report, the human leukemic Tcell line Lyon which expresses a Ti-γδ/CD3 complex, was characterized and compared to another human leukemic Tcell line Jurkat (Ti-αβ/CD3). Membrane TCR−/CD3− variants of the Tcell Lyon were induced and found to produce all of the Ti/CD3 components, with the exception of Ti-δ. Biochemical analysis indicated that: (1) Ti-γ/CD3γ, δ, ε complexes were formed in the endoplasmic reticulum in the absence of Ti-δ; (2) the CD3-ξ chain did not associate with the Ti-γ/CD3γδε complex and (3) the Ti-δ chain was required for cell surface expression of the Ti-γδ/CD3 complex. Introduction of Jurkat wild-type Ti-α cDNA into Lyon T cells resulted in Ti-αβ/CD3 expression and abrogated Ti-γδ/CD3 expression. In contrast, the expression of the Ti-γδ/CD3 complex was not affected by transfection of a mutated Ti-α cDN A into Lyon cells. The mutated Ti-α chain formed complexes with Ti-β and CD3γδε, but the CD3-ξ; chain did not associate with these complexes. Taken together analysis of Lyon cells transfected with either wild-type or mutated Ti-α suggested that the CD3-ξ, chain may have higher affinity for Ti-αβ/CD3 complexes than for Ti-γδ/CD3 complexes." @default.
- W2008340920 created "2016-06-24" @default.
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- W2008340920 date "1993-02-01" @default.
- W2008340920 modified "2023-10-18" @default.
- W2008340920 title "Characterization of T cell receptor assembly and expression in a Ti γδ-positive cell line" @default.
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- W2008340920 doi "https://doi.org/10.1002/eji.1830230228" @default.
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