Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008343350> ?p ?o ?g. }
- W2008343350 endingPage "95" @default.
- W2008343350 startingPage "86" @default.
- W2008343350 abstract "Several aspects of the mechanism of homologous double-strand break repair remain unclear. Although intensive efforts have focused on how recombination reactions initiate, far less is known about the molecular events that follow. Based upon biochemical studies, current models propose that RecBCD processes double-strand ends and loads RecA to initiate recombinational repair. However, recent studies have shown that RecBCD plays a critical role in completing replication events on the chromosome through a mechanism that does not involve RecA or recombination. Here, we examine several studies, both early and recent, that suggest RecBCD also operates late in the recombination process - after initiation, strand invasion, and crossover resolution have occurred. Similar to its role in completing replication, we propose a model in which RecBCD is required to resect and resolve the DNA synthesis associated with homologous recombination at the point where the missing sequences on the broken molecule have been restored. We explain how the impaired ability to complete chromosome replication in recBC and recD mutants is likely to account for the loss of viability and genome instability in these mutants, and conclude that spontaneous double-strand breaks and replication fork collapse occur far less frequently than previously speculated." @default.
- W2008343350 created "2016-06-24" @default.
- W2008343350 creator A5013252820 @default.
- W2008343350 creator A5024620549 @default.
- W2008343350 creator A5047616364 @default.
- W2008343350 creator A5066453815 @default.
- W2008343350 date "2015-08-01" @default.
- W2008343350 modified "2023-09-27" @default.
- W2008343350 title "RecBCD is required to complete chromosomal replication: Implications for double-strand break frequencies and repair mechanisms" @default.
- W2008343350 cites W148173028 @default.
- W2008343350 cites W1482268197 @default.
- W2008343350 cites W1510960581 @default.
- W2008343350 cites W1524832724 @default.
- W2008343350 cites W1525549859 @default.
- W2008343350 cites W1527634644 @default.
- W2008343350 cites W1539873590 @default.
- W2008343350 cites W1561261364 @default.
- W2008343350 cites W1564890115 @default.
- W2008343350 cites W1570361288 @default.
- W2008343350 cites W1574517022 @default.
- W2008343350 cites W1585593039 @default.
- W2008343350 cites W1596893590 @default.
- W2008343350 cites W16006842 @default.
- W2008343350 cites W1619674734 @default.
- W2008343350 cites W1668171824 @default.
- W2008343350 cites W1800294584 @default.
- W2008343350 cites W1833676004 @default.
- W2008343350 cites W1930393440 @default.
- W2008343350 cites W1947419543 @default.
- W2008343350 cites W1964831588 @default.
- W2008343350 cites W1968288171 @default.
- W2008343350 cites W1971198145 @default.
- W2008343350 cites W1972510374 @default.
- W2008343350 cites W1972522403 @default.
- W2008343350 cites W1973154704 @default.
- W2008343350 cites W1973655646 @default.
- W2008343350 cites W1973964227 @default.
- W2008343350 cites W1976316051 @default.
- W2008343350 cites W1976567461 @default.
- W2008343350 cites W1977843113 @default.
- W2008343350 cites W1981569373 @default.
- W2008343350 cites W1987950789 @default.
- W2008343350 cites W1989115806 @default.
- W2008343350 cites W1989659941 @default.
- W2008343350 cites W1989798735 @default.
- W2008343350 cites W1991988366 @default.
- W2008343350 cites W1992510514 @default.
- W2008343350 cites W1993303177 @default.
- W2008343350 cites W1994751550 @default.
- W2008343350 cites W1995004577 @default.
- W2008343350 cites W2000466842 @default.
- W2008343350 cites W2003239553 @default.
- W2008343350 cites W2003719212 @default.
- W2008343350 cites W2004760238 @default.
- W2008343350 cites W2005402849 @default.
- W2008343350 cites W2006117726 @default.
- W2008343350 cites W2008138719 @default.
- W2008343350 cites W2013677972 @default.
- W2008343350 cites W2016498953 @default.
- W2008343350 cites W2018405580 @default.
- W2008343350 cites W2018841459 @default.
- W2008343350 cites W2020490067 @default.
- W2008343350 cites W2020679229 @default.
- W2008343350 cites W2021279906 @default.
- W2008343350 cites W2023479451 @default.
- W2008343350 cites W2025336271 @default.
- W2008343350 cites W2026309158 @default.
- W2008343350 cites W2028622989 @default.
- W2008343350 cites W2033657546 @default.
- W2008343350 cites W2033889514 @default.
- W2008343350 cites W2035027118 @default.
- W2008343350 cites W2037695645 @default.
- W2008343350 cites W2039207927 @default.
- W2008343350 cites W2040092826 @default.
- W2008343350 cites W2040203898 @default.
- W2008343350 cites W2043028465 @default.
- W2008343350 cites W2043198662 @default.
- W2008343350 cites W2044443934 @default.
- W2008343350 cites W2044863330 @default.
- W2008343350 cites W2046066638 @default.
- W2008343350 cites W2051478798 @default.
- W2008343350 cites W2053481131 @default.
- W2008343350 cites W2054123861 @default.
- W2008343350 cites W2064234883 @default.
- W2008343350 cites W2064402458 @default.
- W2008343350 cites W2065719103 @default.
- W2008343350 cites W2067697076 @default.
- W2008343350 cites W2069957134 @default.
- W2008343350 cites W2077086420 @default.
- W2008343350 cites W2079478900 @default.
- W2008343350 cites W2082234447 @default.
- W2008343350 cites W2083370148 @default.
- W2008343350 cites W2083651366 @default.
- W2008343350 cites W2084675062 @default.
- W2008343350 cites W2085866527 @default.
- W2008343350 cites W2086199106 @default.
- W2008343350 cites W2099461281 @default.
- W2008343350 cites W2099958026 @default.