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- W2008344562 abstract "Summary When hepatic microsomes from adult male rats were incubated with microsomal lipids (ML) extracted from the microsomes of neonatal rats, ethylmorphine N-demethylase activity was inhibited by 55%, while aniline hydroxylase activity was not. ML produced a type I spectral change in microsomes of adult rats as did ethylmorphine. The inhibitory component of ML resided in the phospholipid fraction and was destroyed by exposure to O2. ML from adult male rats contained 20% unsaturated fatty acids and were only one-half as potent as those from neonates (38% unsaturated). These results suggest that phospholipid(s) containing unsaturated fatty acids inhibit the metabolism of type I drugs by combining with their binding site, and may be responsible, at least in part, for the low activity of drug metabolism in the neonate." @default.
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- W2008344562 date "1975-08-01" @default.
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- W2008344562 title "Differential inhibition of drug metabolism by hepatic microsomal lipids of neonatal and adult rats" @default.
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- W2008344562 doi "https://doi.org/10.1016/s0006-291x(75)80466-9" @default.
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