Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008345210> ?p ?o ?g. }
- W2008345210 endingPage "1179" @default.
- W2008345210 startingPage "1174" @default.
- W2008345210 abstract "BACKGROUND: Passive infusion of HLA antibodies has been implicated in transfusion reactions. A rapid, inexpensive method of screening blood donors for HLA antibodies might reduce the incidence of reactions. A high‐throughput microbead‐flow analyzer HLA antibody detection technique was compared with an enzyme‐linked immunosorbent assay (ELISA) method. STUDY DESIGN AND METHODS: Ninety‐six apheresis platelet (PLT) donors were tested for antibodies to Class I and II HLA antigens with mixed‐antigen microbead‐flow analyzer and ELISAs. For both assays, samples reactive in the mixed‐antigen assay were tested with a panel‐reactive antibody (PRA) assay. Samples reactive in both the mixed‐antigen and the PRA assays were considered positive. RESULTS: In the mixed‐antigen microbead assay, 46 (48%) samples were reactive to Class I antigens and 20 (21%) to Class II. Further testing in the microbead PRA assay revealed that 34 (35%) had antibodies to Class I antigens, 18 (19%) to Class II, and 42 (44%) to either Class I or Class II. Class I antibodies were present in 56 percent of females and 36 percent of males. In the mixed‐antigen ELISA, 4 samples were reactive with Class I antigens, 4 with Class II antigens, and 5 with Class I or Class II. All 5 reactive samples were also reactive in the ELISA PRA assay and were from females. CONCLUSION: The microbead assay was more sensitive than the ELISA and detected antibodies in a large proportion of donors. Samples reactive in the mixed‐antigen microbead assay should be confirmed by a second assay before concluding that antibodies are present." @default.
- W2008345210 created "2016-06-24" @default.
- W2008345210 creator A5006108181 @default.
- W2008345210 creator A5037877623 @default.
- W2008345210 creator A5046543021 @default.
- W2008345210 creator A5048815910 @default.
- W2008345210 creator A5049201933 @default.
- W2008345210 creator A5059941996 @default.
- W2008345210 creator A5069456738 @default.
- W2008345210 creator A5072166479 @default.
- W2008345210 creator A5090423342 @default.
- W2008345210 date "2008-04-15" @default.
- W2008345210 modified "2023-10-15" @default.
- W2008345210 title "Analysis of a high-throughput HLA antibody screening assay for use with platelet donors" @default.
- W2008345210 cites W1967640548 @default.
- W2008345210 cites W1970457359 @default.
- W2008345210 cites W1981064496 @default.
- W2008345210 cites W1983318857 @default.
- W2008345210 cites W1993546125 @default.
- W2008345210 cites W2012031362 @default.
- W2008345210 cites W2017061127 @default.
- W2008345210 cites W2049275702 @default.
- W2008345210 cites W2070076886 @default.
- W2008345210 cites W2111403445 @default.
- W2008345210 cites W2112844454 @default.
- W2008345210 cites W2162206940 @default.
- W2008345210 cites W2184283604 @default.
- W2008345210 cites W4231936870 @default.
- W2008345210 doi "https://doi.org/10.1111/j.1537-2995.2008.01684.x" @default.
- W2008345210 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2666543" @default.
- W2008345210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18422853" @default.
- W2008345210 hasPublicationYear "2008" @default.
- W2008345210 type Work @default.
- W2008345210 sameAs 2008345210 @default.
- W2008345210 citedByCount "32" @default.
- W2008345210 countsByYear W20083452102012 @default.
- W2008345210 countsByYear W20083452102013 @default.
- W2008345210 countsByYear W20083452102014 @default.
- W2008345210 countsByYear W20083452102015 @default.
- W2008345210 countsByYear W20083452102016 @default.
- W2008345210 countsByYear W20083452102018 @default.
- W2008345210 countsByYear W20083452102020 @default.
- W2008345210 countsByYear W20083452102021 @default.
- W2008345210 crossrefType "journal-article" @default.
- W2008345210 hasAuthorship W2008345210A5006108181 @default.
- W2008345210 hasAuthorship W2008345210A5037877623 @default.
- W2008345210 hasAuthorship W2008345210A5046543021 @default.
- W2008345210 hasAuthorship W2008345210A5048815910 @default.
- W2008345210 hasAuthorship W2008345210A5049201933 @default.
- W2008345210 hasAuthorship W2008345210A5059941996 @default.
- W2008345210 hasAuthorship W2008345210A5069456738 @default.
- W2008345210 hasAuthorship W2008345210A5072166479 @default.
- W2008345210 hasAuthorship W2008345210A5090423342 @default.
- W2008345210 hasBestOaLocation W20083452102 @default.
- W2008345210 hasConcept C147483822 @default.
- W2008345210 hasConcept C153911025 @default.
- W2008345210 hasConcept C159654299 @default.
- W2008345210 hasConcept C185592680 @default.
- W2008345210 hasConcept C188280979 @default.
- W2008345210 hasConcept C203014093 @default.
- W2008345210 hasConcept C2776363448 @default.
- W2008345210 hasConcept C2780420688 @default.
- W2008345210 hasConcept C55493867 @default.
- W2008345210 hasConcept C64518967 @default.
- W2008345210 hasConcept C86803240 @default.
- W2008345210 hasConceptScore W2008345210C147483822 @default.
- W2008345210 hasConceptScore W2008345210C153911025 @default.
- W2008345210 hasConceptScore W2008345210C159654299 @default.
- W2008345210 hasConceptScore W2008345210C185592680 @default.
- W2008345210 hasConceptScore W2008345210C188280979 @default.
- W2008345210 hasConceptScore W2008345210C203014093 @default.
- W2008345210 hasConceptScore W2008345210C2776363448 @default.
- W2008345210 hasConceptScore W2008345210C2780420688 @default.
- W2008345210 hasConceptScore W2008345210C55493867 @default.
- W2008345210 hasConceptScore W2008345210C64518967 @default.
- W2008345210 hasConceptScore W2008345210C86803240 @default.
- W2008345210 hasIssue "6" @default.
- W2008345210 hasLocation W20083452101 @default.
- W2008345210 hasLocation W20083452102 @default.
- W2008345210 hasLocation W20083452103 @default.
- W2008345210 hasLocation W20083452104 @default.
- W2008345210 hasLocation W20083452105 @default.
- W2008345210 hasOpenAccess W2008345210 @default.
- W2008345210 hasPrimaryLocation W20083452101 @default.
- W2008345210 hasRelatedWork W1994680615 @default.
- W2008345210 hasRelatedWork W2053502407 @default.
- W2008345210 hasRelatedWork W2062929029 @default.
- W2008345210 hasRelatedWork W2362702203 @default.
- W2008345210 hasRelatedWork W2376315816 @default.
- W2008345210 hasRelatedWork W2377378607 @default.
- W2008345210 hasRelatedWork W2379121469 @default.
- W2008345210 hasRelatedWork W2394331430 @default.
- W2008345210 hasRelatedWork W3030835380 @default.
- W2008345210 hasRelatedWork W3189567124 @default.
- W2008345210 hasVolume "48" @default.
- W2008345210 isParatext "false" @default.
- W2008345210 isRetracted "false" @default.
- W2008345210 magId "2008345210" @default.