FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008364809> ?p ?o ?g. }

• W2008364809 abstract "Abstract Background The renin-angiotensin-aldosterone system (RAAS) is involved in the cardiovascular homeostasis as shown by previous studies reporting a positive association between specific RAAS genotypes and an increased risk of myocardial infarction. Anyhow the prognostic role in a long-term follow-up has not been yet investigated. Aim of the study was to evaluate the influence of the most studied RAAS genetic Single Nucleotide Polymorphisms (SNPs) on the occurrence and the long-term prognosis of acute myocardial infarction (AMI) at young age in an Italian population. Methods The study population consisted of 201 patients and 201 controls, matched for age and sex (mean age 40 ± 4 years; 90.5% males). The most frequent conventional risk factors were smoke (p < 0.001), family history for coronary artery diseases (p < 0.001), hypercholesterolemia (p = 0.001) and hypertension (p = 0.002). The tested genetic polymorphisms were angiotensin converting enzyme insertion/deletion (ACE I/D), angiotensin II type 1 receptor (AGTR1) A1166C and aldosterone synthase (CYP11B2) C-344T. Considering a long-term follow-up (9 ± 4 years) we compared genetic polymorphisms of patients with and without events (cardiac death, myocardial infarction, revascularization procedures). Results We found a borderline significant association of occurrence of AMI with the ACE D/I polymorphism (DD genotype, 42% in cases vs 31% in controls; p = 0.056). DD genotype remained statistically involved in the incidence of AMI also after adjustment for clinical confounders. On the other hand, during the 9-year follow-up (65 events, including 13 deaths) we found a role concerning the AGTR1: the AC heterozygous resulted more represented in the event group (p = 0.016) even if not independent from clinical confounders. Anyhow the Kaplan-Meier event free curves seem to confirm the unfavourable role of this polymorphism. Conclusion Polymorphisms in RAAS genes can be important in the onset of a first AMI in young patients (ACE, CYP11B2 polymorphisms), but not in the disease progression after a long follow-up period. Larger collaborative studies are needed to confirm these results." @default.
• W2008364809 created "2016-06-24" @default.
• W2008364809 creator A5004787931 @default.
• W2008364809 creator A5010867611 @default.
• W2008364809 creator A5017849465 @default.
• W2008364809 creator A5032378624 @default.
• W2008364809 creator A5071699549 @default.
• W2008364809 creator A5074905374 @default.
• W2008364809 creator A5076923890 @default.
• W2008364809 creator A5080247179 @default.
• W2008364809 creator A5090055085 @default.
• W2008364809 date "2007-05-22" @default.
• W2008364809 modified "2023-10-02" @default.
• W2008364809 title "Renin-angiotensin-aldosterone system polymorphisms: a role or a hole in occurrence and long-term prognosis of acute myocardial infarction at young age" @default.
• W2008364809 cites W1969051402 @default.
• W2008364809 cites W2012888011 @default.
• W2008364809 cites W2024735537 @default.
• W2008364809 cites W2035330926 @default.
• W2008364809 cites W2037334643 @default.
• W2008364809 cites W2043600435 @default.
• W2008364809 cites W2044244715 @default.
• W2008364809 cites W2050839194 @default.
• W2008364809 cites W2057170733 @default.
• W2008364809 cites W2068870577 @default.
• W2008364809 cites W2073641636 @default.
• W2008364809 cites W2080966519 @default.
• W2008364809 cites W2105504284 @default.
• W2008364809 cites W2109921650 @default.
• W2008364809 cites W2111909217 @default.
• W2008364809 cites W2118094114 @default.
• W2008364809 cites W2130501592 @default.
• W2008364809 cites W2136785799 @default.
• W2008364809 cites W2139376627 @default.
• W2008364809 cites W2142604754 @default.
• W2008364809 cites W2143643832 @default.
• W2008364809 cites W2159449551 @default.
• W2008364809 cites W2318650522 @default.
• W2008364809 cites W2414683748 @default.
• W2008364809 cites W3215088586 @default.
• W2008364809 cites W4230870013 @default.
• W2008364809 cites W4242459468 @default.
• W2008364809 cites W4253293696 @default.
• W2008364809 doi "https://doi.org/10.1186/1471-2350-8-27" @default.
• W2008364809 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1890543" @default.
• W2008364809 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17519002" @default.
• W2008364809 hasPublicationYear "2007" @default.
• W2008364809 type Work @default.
• W2008364809 sameAs 2008364809 @default.
• W2008364809 citedByCount "25" @default.
• W2008364809 countsByYear W20083648092012 @default.
• W2008364809 countsByYear W20083648092013 @default.
• W2008364809 countsByYear W20083648092014 @default.
• W2008364809 countsByYear W20083648092015 @default.
• W2008364809 countsByYear W20083648092016 @default.
• W2008364809 countsByYear W20083648092017 @default.
• W2008364809 countsByYear W20083648092018 @default.
• W2008364809 countsByYear W20083648092019 @default.
• W2008364809 countsByYear W20083648092020 @default.
• W2008364809 countsByYear W20083648092023 @default.
• W2008364809 crossrefType "journal-article" @default.
• W2008364809 hasAuthorship W2008364809A5004787931 @default.
• W2008364809 hasAuthorship W2008364809A5010867611 @default.
• W2008364809 hasAuthorship W2008364809A5017849465 @default.
• W2008364809 hasAuthorship W2008364809A5032378624 @default.
• W2008364809 hasAuthorship W2008364809A5071699549 @default.
• W2008364809 hasAuthorship W2008364809A5074905374 @default.
• W2008364809 hasAuthorship W2008364809A5076923890 @default.
• W2008364809 hasAuthorship W2008364809A5080247179 @default.
• W2008364809 hasAuthorship W2008364809A5090055085 @default.
• W2008364809 hasBestOaLocation W20083648091 @default.
• W2008364809 hasConcept C104317684 @default.
• W2008364809 hasConcept C126322002 @default.
• W2008364809 hasConcept C134018914 @default.
• W2008364809 hasConcept C135763542 @default.
• W2008364809 hasConcept C153209595 @default.
• W2008364809 hasConcept C164705383 @default.
• W2008364809 hasConcept C198710026 @default.
• W2008364809 hasConcept C2778525890 @default.
• W2008364809 hasConcept C2780249997 @default.
• W2008364809 hasConcept C2908647359 @default.
• W2008364809 hasConcept C2908929049 @default.
• W2008364809 hasConcept C500558357 @default.
• W2008364809 hasConcept C54355233 @default.
• W2008364809 hasConcept C71924100 @default.
• W2008364809 hasConcept C84393581 @default.
• W2008364809 hasConcept C86803240 @default.
• W2008364809 hasConcept C99454951 @default.
• W2008364809 hasConceptScore W2008364809C104317684 @default.
• W2008364809 hasConceptScore W2008364809C126322002 @default.
• W2008364809 hasConceptScore W2008364809C134018914 @default.
• W2008364809 hasConceptScore W2008364809C135763542 @default.
• W2008364809 hasConceptScore W2008364809C153209595 @default.
• W2008364809 hasConceptScore W2008364809C164705383 @default.
• W2008364809 hasConceptScore W2008364809C198710026 @default.
• W2008364809 hasConceptScore W2008364809C2778525890 @default.
• W2008364809 hasConceptScore W2008364809C2780249997 @default.
• W2008364809 hasConceptScore W2008364809C2908647359 @default.
• W2008364809 hasConceptScore W2008364809C2908929049 @default.
• W2008364809 hasConceptScore W2008364809C500558357 @default.
• W2008364809 hasConceptScore W2008364809C54355233 @default.

• next