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- W2008366306 abstract "In einer (Langzeit-)Studie an Ratten wurde der Einfluß unterschiedlicher DL-α-Tocopherolzulagen: Gruppe (A) keine, (B) 10, (C) 60 und (D) 100 ppm zu einem polyenfettsäurereichen Triglyceridgemisch (P/S-Quotient: 5.57) auf Plasmalipide (GL, PL, TG, GCH) und Tocopherolstatus (Tocopherolgehalt und in-vitro-Hämolyseneigung der Erythrozyten, CK im Plasma) ermittelt. Eine ausreichende Tocopherolversorgung wurde ab 60 ppm DL-α-Tocopherol im Futter erreicht. Deutlich zeigte sich der Einfluß unterschiedlicher Tocopherolmengen in der Nahrung auch auf die Plasmalipide: Mit steigender Tocopherolzufuhr stiegen die Plasmalipide an. Bei einem Vergleich dieser Studie mit zwei vorangegangenen zeigte sich, daß DL-γ-Tocopherol - in biologisch äquivalenten Mengen - die gleichen Auswirkungen auf die Plasmalipide hat wie das DL-α-Tocopherol, auch bei Zufuhr unterschiedlicher Fettarten. Die Ergebnisse legen nahe, bei Tocopherolsupplementierung Tocopherolstatus und Plasmalipide zu überwachen. Eine Tocopherolüberversorgung könnte die Plasmalipide unerwünscht erhöhen. Relationship between Tocopherol Status and Plasma Lipids - Experiments with Rats In experiments with male rats the effect of different doses of dl-α-tocopherol added to a synthetic triglycerid (P/S-ratio: 5.57) on the level of plasma lipids (TL, PL, TG, TCH) and tocopherolstatus (tocopherolcontent and in vitro hemolysis of erythrocytes, CK in plasma) was investigated. An adequate tocopherolstatus was achieved from the supplementation of 60 ppm dl-α-tocopherol on in the diet. The influence of different doses of tocopherol in the diet on the plasma lipids, too, was clearly demonstrated: with increasing doses of tocopherol the plasma lipids increased. This study was compared with two former studies, which revealed that dl-γ-tocopherol - if supplemented in biological equivalent amounts - had the same effect on plasma lipids as dl-α-tocopherol, regardless what kind of fat was fed. The findings of our study suggest to check tocopherolstatus and plasma lipids in the case of tocopherol supplementation. Excess tocopherol supplementation might increase plasma lipids, which is undesireable." @default.
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- W2008366306 date "1983-01-01" @default.
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- W2008366306 title "Beziehungen zwischen dem Tocopherolstatus und Plasmalipiden am Beispiel der Ratte" @default.
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- W2008366306 doi "https://doi.org/10.1002/lipi.19830851402" @default.
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