FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008374407> ?p ?o ?g. }

• W2008374407 endingPage "748" @default.
• W2008374407 startingPage "739" @default.
• W2008374407 abstract "We hypothesized that network analysis is useful to expose coordination between whole body and myocellular levels of energy metabolism and can identify entities that underlie skeletal muscle's contribution to growth hormone-stimulated lipid handling and metabolic fitness. We assessed 112 metabolic parameters characterizing metabolic rate and substrate handling in tibialis anterior muscle and vascular compartment at rest, after a meal and exercise with growth hormone replacement therapy (GH-RT) of hypopituitary patients ( n = 11). The topology of linear relationships (| r | ≥ 0.7, P ≤ 0.01) and mutual dependencies exposed the organization of metabolic relationships in three entities reflecting basal and exercise-induced metabolic rate, triglyceride handling, and substrate utilization in the pre- and postprandial state, respectively. GH-RT improved aerobic performance (+5%), lean-to-fat mass (+19%), and muscle area of tibialis anterior (+2%) but did not alter its mitochondrial and capillary content. Concomitantly, connectivity was established between myocellular parameters of mitochondrial lipid metabolism and meal-induced triglyceride handling in serum. This was mediated via the recruitment of transcripts of muscle lipid mobilization (LIPE, FABP3, and FABP4) and fatty acid-sensitive transcription factors (PPARA, PPARG) to the metabolic network. The interdependence of gene regulatory elements of muscle lipid metabolism reflected the norm in healthy subjects ( n = 12) and distinguished the regulation of the mitochondrial respiration factor COX1 by GH and endurance exercise. Our observations validate the use of network analysis for systems medicine and highlight the notion that an improved stochiometry between muscle and whole body lipid metabolism, rather than alterations of single bottlenecks, contributes to GH-driven elevations in metabolic fitness." @default.
• W2008374407 created "2016-06-24" @default.
• W2008374407 creator A5012306845 @default.
• W2008374407 creator A5018334277 @default.
• W2008374407 creator A5025662620 @default.
• W2008374407 creator A5060590579 @default.
• W2008374407 creator A5078837444 @default.
• W2008374407 date "2011-06-01" @default.
• W2008374407 modified "2023-09-26" @default.
• W2008374407 title "Regulation of whole body energy homeostasis with growth hormone replacement therapy and endurance exercise" @default.
• W2008374407 cites W154541079 @default.
• W2008374407 cites W1590479106 @default.
• W2008374407 cites W1919144364 @default.
• W2008374407 cites W1944067293 @default.
• W2008374407 cites W1956415557 @default.
• W2008374407 cites W1969804786 @default.
• W2008374407 cites W1981428739 @default.
• W2008374407 cites W1982685226 @default.
• W2008374407 cites W1985023326 @default.
• W2008374407 cites W1992267452 @default.
• W2008374407 cites W1997578267 @default.
• W2008374407 cites W2000500061 @default.
• W2008374407 cites W2006869437 @default.
• W2008374407 cites W2007587754 @default.
• W2008374407 cites W2013522363 @default.
• W2008374407 cites W2036748909 @default.
• W2008374407 cites W2048674295 @default.
• W2008374407 cites W2055531877 @default.
• W2008374407 cites W2055815985 @default.
• W2008374407 cites W2057492342 @default.
• W2008374407 cites W2099337292 @default.
• W2008374407 cites W2104259296 @default.
• W2008374407 cites W2109637109 @default.
• W2008374407 cites W2111850203 @default.
• W2008374407 cites W2115537652 @default.
• W2008374407 cites W2144342921 @default.
• W2008374407 cites W2145025818 @default.
• W2008374407 cites W2158488137 @default.
• W2008374407 cites W2161570633 @default.
• W2008374407 cites W2169478906 @default.
• W2008374407 cites W2170749940 @default.
• W2008374407 doi "https://doi.org/10.1152/physiolgenomics.00034.2010" @default.
• W2008374407 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21447747" @default.
• W2008374407 hasPublicationYear "2011" @default.
• W2008374407 type Work @default.
• W2008374407 sameAs 2008374407 @default.
• W2008374407 citedByCount "8" @default.
• W2008374407 countsByYear W20083744072012 @default.
• W2008374407 countsByYear W20083744072014 @default.
• W2008374407 countsByYear W20083744072015 @default.
• W2008374407 countsByYear W20083744072016 @default.
• W2008374407 countsByYear W20083744072018 @default.
• W2008374407 countsByYear W20083744072020 @default.
• W2008374407 crossrefType "journal-article" @default.
• W2008374407 hasAuthorship W2008374407A5012306845 @default.
• W2008374407 hasAuthorship W2008374407A5018334277 @default.
• W2008374407 hasAuthorship W2008374407A5025662620 @default.
• W2008374407 hasAuthorship W2008374407A5060590579 @default.
• W2008374407 hasAuthorship W2008374407A5078837444 @default.
• W2008374407 hasConcept C103038586 @default.
• W2008374407 hasConcept C126322002 @default.
• W2008374407 hasConcept C134018914 @default.
• W2008374407 hasConcept C17093226 @default.
• W2008374407 hasConcept C2491326 @default.
• W2008374407 hasConcept C2778163477 @default.
• W2008374407 hasConcept C2778199505 @default.
• W2008374407 hasConcept C2778913445 @default.
• W2008374407 hasConcept C2779306644 @default.
• W2008374407 hasConcept C2779959927 @default.
• W2008374407 hasConcept C4733338 @default.
• W2008374407 hasConcept C511355011 @default.
• W2008374407 hasConcept C71924100 @default.
• W2008374407 hasConcept C86803240 @default.
• W2008374407 hasConceptScore W2008374407C103038586 @default.
• W2008374407 hasConceptScore W2008374407C126322002 @default.
• W2008374407 hasConceptScore W2008374407C134018914 @default.
• W2008374407 hasConceptScore W2008374407C17093226 @default.
• W2008374407 hasConceptScore W2008374407C2491326 @default.
• W2008374407 hasConceptScore W2008374407C2778163477 @default.
• W2008374407 hasConceptScore W2008374407C2778199505 @default.
• W2008374407 hasConceptScore W2008374407C2778913445 @default.
• W2008374407 hasConceptScore W2008374407C2779306644 @default.
• W2008374407 hasConceptScore W2008374407C2779959927 @default.
• W2008374407 hasConceptScore W2008374407C4733338 @default.
• W2008374407 hasConceptScore W2008374407C511355011 @default.
• W2008374407 hasConceptScore W2008374407C71924100 @default.
• W2008374407 hasConceptScore W2008374407C86803240 @default.
• W2008374407 hasIssue "12" @default.
• W2008374407 hasLocation W20083744071 @default.
• W2008374407 hasLocation W20083744072 @default.
• W2008374407 hasOpenAccess W2008374407 @default.
• W2008374407 hasPrimaryLocation W20083744071 @default.
• W2008374407 hasRelatedWork W1989118375 @default.
• W2008374407 hasRelatedWork W2000347764 @default.
• W2008374407 hasRelatedWork W2022501281 @default.
• W2008374407 hasRelatedWork W2030149161 @default.
• W2008374407 hasRelatedWork W2130042602 @default.
• W2008374407 hasRelatedWork W2142407152 @default.

• next