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- W2008381640 abstract "Oxidation of alcohols and amines is catalyzed by multiple families of flavin- and pyridine nucleotide-dependent enzymes. Measurement of solvent isotope effects provides a unique mechanistic probe of the timing of the cleavage of the OH and NH bonds, necessary information for a complete description of the catalytic mechanism. The inherent ambiguities in interpretation of solvent isotope effects can be significantly decreased if isotope effects arising from isotopically labeled substrates are measured in combination with solvent isotope effects. The application of combined solvent and substrate (mainly deuterium) isotope effects to multiple enzymes is described here to illustrate the range of mechanistic insights that such an approach can provide. This article is part of a Special Issue entitled: Enzyme Transition States from Theory and Experiment." @default.
- W2008381640 created "2016-06-24" @default.
- W2008381640 creator A5053442721 @default.
- W2008381640 date "2015-11-01" @default.
- W2008381640 modified "2023-10-16" @default.
- W2008381640 title "Combining solvent isotope effects with substrate isotope effects in mechanistic studies of alcohol and amine oxidation by enzymes" @default.
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- W2008381640 doi "https://doi.org/10.1016/j.bbapap.2014.10.020" @default.
- W2008381640 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4416078" @default.
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