FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008386989> ?p ?o ?g. }

• W2008386989 endingPage "359" @default.
• W2008386989 startingPage "349" @default.
• W2008386989 abstract "Traumatic brain injury (TBI) is the one of the most common forms of head trauma, and it remains a leading cause of death and disability. It is known that the initial mechanical axonal injury triggers a complex cascade of neuroinflammatory and metabolic events, the understanding of which is essential for clinical, translational, and pharmacological research. These can occur even in mild TBI, and are associated with several post-concussion manifestations, including transiently heightened vulnerability to a second insult. Recent studies have challenged the tenet that ischemia is the ultimate modality of tissue damage following TBI, as metabolic dysfunction can develop in the presence of normal perfusion and before intracranial hypertension. In order to elucidate the cellular and molecular changes occurring in TBI as a direct result of neuronal injury and in the absence of ischemic damage, we performed a microarray analysis of expressed genes and molecular interaction pathways for different levels of severity of trauma using an in-vitro model. A stretch injury, equivalent to human diffuse axonal injury, was delivered to rat organotypic hippocampal slice cultures, and mRNA levels following a 10% (mild) and 50% (severe) stretch were compared with controls at 24 h. More genes were differentially expressed following 10% stretch than 50% stretch, indicating the early activation of complex cellular mechanisms. The data revealed remarkable differential gene expression following mTBI, even in the absence of cell damage. Pathway analysis revealed that molecular interactions in both levels of injury were similar, with IL-1β playing a central role. Additional pathways of neurodegeneration involving RhoA (ras homolog gene family, member A) were found in 50% stretch." @default.
• W2008386989 created "2016-06-24" @default.
• W2008386989 creator A5007788517 @default.
• W2008386989 creator A5026488359 @default.
• W2008386989 creator A5044073870 @default.
• W2008386989 creator A5047972775 @default.
• W2008386989 creator A5049415219 @default.
• W2008386989 creator A5069322554 @default.
• W2008386989 creator A5070438968 @default.
• W2008386989 creator A5077540699 @default.
• W2008386989 date "2010-02-01" @default.
• W2008386989 modified "2023-10-16" @default.
• W2008386989 title "Transcriptomics of Traumatic Brain Injury: Gene Expression and Molecular Pathways of Different Grades of Insult in a Rat Organotypic Hippocampal Culture Model" @default.
• W2008386989 cites W1524495606 @default.
• W2008386989 cites W1594425991 @default.
• W2008386989 cites W1603121691 @default.
• W2008386989 cites W1967893879 @default.
• W2008386989 cites W1978585388 @default.
• W2008386989 cites W1996370667 @default.
• W2008386989 cites W2000663601 @default.
• W2008386989 cites W2000730164 @default.
• W2008386989 cites W2022697435 @default.
• W2008386989 cites W2023768396 @default.
• W2008386989 cites W2031033928 @default.
• W2008386989 cites W2034317293 @default.
• W2008386989 cites W2038037402 @default.
• W2008386989 cites W2047324209 @default.
• W2008386989 cites W2067051297 @default.
• W2008386989 cites W2067487401 @default.
• W2008386989 cites W2069333565 @default.
• W2008386989 cites W2082498537 @default.
• W2008386989 cites W2083952664 @default.
• W2008386989 cites W2086603898 @default.
• W2008386989 cites W2091132928 @default.
• W2008386989 cites W2097698606 @default.
• W2008386989 cites W2098731968 @default.
• W2008386989 cites W2100986512 @default.
• W2008386989 cites W2116242136 @default.
• W2008386989 cites W2126022615 @default.
• W2008386989 cites W2130410032 @default.
• W2008386989 cites W2154634289 @default.
• W2008386989 cites W2164740405 @default.
• W2008386989 cites W2171862886 @default.
• W2008386989 cites W289221030 @default.
• W2008386989 cites W4376849382 @default.
• W2008386989 doi "https://doi.org/10.1089/neu.2009.1095" @default.
• W2008386989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19903084" @default.
• W2008386989 hasPublicationYear "2010" @default.
• W2008386989 type Work @default.
• W2008386989 sameAs 2008386989 @default.
• W2008386989 citedByCount "52" @default.
• W2008386989 countsByYear W20083869892012 @default.
• W2008386989 countsByYear W20083869892013 @default.
• W2008386989 countsByYear W20083869892014 @default.
• W2008386989 countsByYear W20083869892015 @default.
• W2008386989 countsByYear W20083869892016 @default.
• W2008386989 countsByYear W20083869892017 @default.
• W2008386989 countsByYear W20083869892018 @default.
• W2008386989 countsByYear W20083869892019 @default.
• W2008386989 countsByYear W20083869892020 @default.
• W2008386989 countsByYear W20083869892021 @default.
• W2008386989 countsByYear W20083869892022 @default.
• W2008386989 countsByYear W20083869892023 @default.
• W2008386989 crossrefType "journal-article" @default.
• W2008386989 hasAuthorship W2008386989A5007788517 @default.
• W2008386989 hasAuthorship W2008386989A5026488359 @default.
• W2008386989 hasAuthorship W2008386989A5044073870 @default.
• W2008386989 hasAuthorship W2008386989A5047972775 @default.
• W2008386989 hasAuthorship W2008386989A5049415219 @default.
• W2008386989 hasAuthorship W2008386989A5069322554 @default.
• W2008386989 hasAuthorship W2008386989A5070438968 @default.
• W2008386989 hasAuthorship W2008386989A5077540699 @default.
• W2008386989 hasConcept C118552586 @default.
• W2008386989 hasConcept C126322002 @default.
• W2008386989 hasConcept C141071460 @default.
• W2008386989 hasConcept C142724271 @default.
• W2008386989 hasConcept C148762608 @default.
• W2008386989 hasConcept C169760540 @default.
• W2008386989 hasConcept C190385971 @default.
• W2008386989 hasConcept C2775855016 @default.
• W2008386989 hasConcept C2776925932 @default.
• W2008386989 hasConcept C2777093181 @default.
• W2008386989 hasConcept C2778426673 @default.
• W2008386989 hasConcept C2779134260 @default.
• W2008386989 hasConcept C2781017439 @default.
• W2008386989 hasConcept C2781458332 @default.
• W2008386989 hasConcept C2994141250 @default.
• W2008386989 hasConcept C3017944768 @default.
• W2008386989 hasConcept C541997718 @default.
• W2008386989 hasConcept C62478195 @default.
• W2008386989 hasConcept C71924100 @default.
• W2008386989 hasConcept C86803240 @default.
• W2008386989 hasConcept C95444343 @default.
• W2008386989 hasConcept C99454951 @default.
• W2008386989 hasConceptScore W2008386989C118552586 @default.
• W2008386989 hasConceptScore W2008386989C126322002 @default.
• W2008386989 hasConceptScore W2008386989C141071460 @default.
• W2008386989 hasConceptScore W2008386989C142724271 @default.

• next