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• W2008390111 abstract "Bombesin, acetylcholine, prostaglandins and somatostatin are all thought to be involved in the regulation of gastrin release and gastric secretion. We have studied the effects of low doses of atropine, 16-16(Me) 2 -prostaglandin E 2 (PGE 2 ) and somatostatin-14 on bombesin-stimulated gastrin release and gastric acid and pepsin secretion in conscious fistula dogs. For reference, synthetic gastrin G-17 was studied with and without somatostatin. Bombesin, in a dose-related manner, increased serum gastrin, which in turn stimulated gastric acid and pepsin secretion in a serum gastrin, concentration-dependent manner. Somatostatin inhibited gastrin release by bombesin as well as the secretory stimulation by G-17; the combination of sequential effects resulted in a marked inhibition of bombesin-stimulated gastric acid and pepsin secretion. PGE 2 also strongly inhibited gastrin release and acid and pepsin secretion. Atropine had no significant effect on gastrin release, but greatly inhibited gastric secretion. Thus somatostatin and PGE 2 inhibited at two sites, gastrin release and gastrin effects, while atropine affected only the latter." @default.
• W2008390111 created "2016-06-24" @default.
• W2008390111 creator A5015637860 @default.
• W2008390111 creator A5042593462 @default.
• W2008390111 date "1984-01-01" @default.
• W2008390111 modified "2023-09-26" @default.
• W2008390111 title "Somatostatin, prostaglandin E2 and atropine inhibition of the gastric actions of bombesin in the dog" @default.
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• W2008390111 doi "https://doi.org/10.1016/0196-9781(84)90046-9" @default.
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