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• W2008403724 abstract "Epitope-based vaccines designed to induce cellular immune response and antibody responses specific for infectious bronchitis virus (IBV) are being developed as a means for increasing vaccine potency. In this study, we selected seven epitopes from the spike (S1), spike (S2), and nucleocapsid (N) protein and constructed a multi-epitope DNA vaccine. The 7-day-old chickens were immunized intramuscularly with multi-epitope DNA vaccine encapsulated by liposome and boosted two weeks later, and were challenged by virulent IBV strain five weeks post booster. The results showed that multi-epitope DNA vaccine led to a dramatic augmentation of humoral and cellular responses, and provided up to 80.0% rate of immune protection. The novel immunogenic chimeric multi-epitope DNA vaccine revealed in this study provided a new candidate target for IBV vaccine development." @default.
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• W2008403724 date "2008-12-01" @default.
• W2008403724 modified "2023-10-14" @default.
• W2008403724 title "The immunoreactivity of a chimeric multi-epitope DNA vaccine against IBV in chickens" @default.
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• W2008403724 doi "https://doi.org/10.1016/j.bbrc.2008.09.125" @default.
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