FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008409819> ?p ?o ?g. }

• W2008409819 endingPage "721" @default.
• W2008409819 startingPage "713" @default.
• W2008409819 abstract "Signal transducers and activators of transcription (STATs) comprise a family of several transcription factors that are activated by a variety of cytokines, hormones and growth factors. STATs are activated through tyrosine phosphorylation, mainly by JAK kinases, which lead to their dimerization, nuclear translocation and regulation of target genes expression. Stringent mechanisms of signal attenuation are essential for insuring appropriate, controlled cellular responses. Among them phosphotyrosine phosphatases (SHPs, CD45, PTP1B/TC-PTP), protein inhibitors of activated STATs (PIAS) and suppressors of cytokine signaling (SOCS) inhibit specific and distinct aspects of cytokine signal transduction. SOCS proteins bind through their SH2 domain to phosphotyrosine residues in either cytokine receptors or JAK and thus can suppress cytokine signaling. Many recent findings indicate that SOCS proteins act, in addition, as adaptors that regulate the turnover of certain substrates by interacting with and activating an E3 ubiquitin ligase. Thus, SOCS proteins act as negative regulators of JAK/STAT pathways and may represent tumour suppressor genes. The discovery of oncogenic partner in this signaling pathway, more especially in diverse hematologic malignancies support a prominent role of deregulated pathways in the pathogenesis of diseases. Fusion proteins implicating the JH1 domain of JAK2 (TEL-JAK2, BCR-JAK2), leading to deregulated activity of JAK2, have been described as the result of translocation. Somatic point mutation in JH2 domain of JAK2 (JAK2V617F), leading also to constitutive tyrosine phosphorylation of JAK2 and its downstream effectors was reported in myeloproliferative disorders. Furthermore, silencing of socs-1 and shp-1 expression by gene methylation is observed in some cancer cells." @default.
• W2008409819 created "2016-06-24" @default.
• W2008409819 creator A5004065684 @default.
• W2008409819 creator A5023118551 @default.
• W2008409819 date "2006-03-01" @default.
• W2008409819 modified "2023-10-06" @default.
• W2008409819 title "JAK/STAT signal transduction: Regulators and implication in hematological malignancies" @default.
• W2008409819 cites W1488478985 @default.
• W2008409819 cites W1526121547 @default.
• W2008409819 cites W1556996865 @default.
• W2008409819 cites W1569274669 @default.
• W2008409819 cites W1648663357 @default.
• W2008409819 cites W1668039320 @default.
• W2008409819 cites W1913308048 @default.
• W2008409819 cites W1967894253 @default.
• W2008409819 cites W1968885796 @default.
• W2008409819 cites W1970925130 @default.
• W2008409819 cites W1971695831 @default.
• W2008409819 cites W1972112588 @default.
• W2008409819 cites W1976665551 @default.
• W2008409819 cites W1976989643 @default.
• W2008409819 cites W1980531181 @default.
• W2008409819 cites W1980568348 @default.
• W2008409819 cites W1981515025 @default.
• W2008409819 cites W1985384612 @default.
• W2008409819 cites W1985723042 @default.
• W2008409819 cites W1987485969 @default.
• W2008409819 cites W1991601985 @default.
• W2008409819 cites W1992965385 @default.
• W2008409819 cites W1993034428 @default.
• W2008409819 cites W1993520606 @default.
• W2008409819 cites W1999608888 @default.
• W2008409819 cites W2000367646 @default.
• W2008409819 cites W2000813775 @default.
• W2008409819 cites W2001158436 @default.
• W2008409819 cites W2002246876 @default.
• W2008409819 cites W2015061405 @default.
• W2008409819 cites W2015859607 @default.
• W2008409819 cites W2024651218 @default.
• W2008409819 cites W2025236720 @default.
• W2008409819 cites W2029169197 @default.
• W2008409819 cites W2029389376 @default.
• W2008409819 cites W2035130253 @default.
• W2008409819 cites W2038468714 @default.
• W2008409819 cites W2040257851 @default.
• W2008409819 cites W2042011247 @default.
• W2008409819 cites W2046256825 @default.
• W2008409819 cites W2047490254 @default.
• W2008409819 cites W2049145190 @default.
• W2008409819 cites W2053334297 @default.
• W2008409819 cites W2053544216 @default.
• W2008409819 cites W2054060377 @default.
• W2008409819 cites W2055549992 @default.
• W2008409819 cites W2057102020 @default.
• W2008409819 cites W2057360098 @default.
• W2008409819 cites W2060402899 @default.
• W2008409819 cites W2061458035 @default.
• W2008409819 cites W2069711307 @default.
• W2008409819 cites W2069993678 @default.
• W2008409819 cites W2071274943 @default.
• W2008409819 cites W2082298729 @default.
• W2008409819 cites W2082448876 @default.
• W2008409819 cites W2083189092 @default.
• W2008409819 cites W2083802827 @default.
• W2008409819 cites W2084201114 @default.
• W2008409819 cites W2085580043 @default.
• W2008409819 cites W2088203127 @default.
• W2008409819 cites W2089889294 @default.
• W2008409819 cites W2093184750 @default.
• W2008409819 cites W2098437309 @default.
• W2008409819 cites W2100930825 @default.
• W2008409819 cites W2104485296 @default.
• W2008409819 cites W2105949419 @default.
• W2008409819 cites W2107690874 @default.
• W2008409819 cites W2114713566 @default.
• W2008409819 cites W2116988305 @default.
• W2008409819 cites W2118310862 @default.
• W2008409819 cites W2119596771 @default.
• W2008409819 cites W2120006659 @default.
• W2008409819 cites W2124489640 @default.
• W2008409819 cites W2126150441 @default.
• W2008409819 cites W2131666890 @default.
• W2008409819 cites W2132678405 @default.
• W2008409819 cites W2142574099 @default.
• W2008409819 cites W2142775607 @default.
• W2008409819 cites W2142962849 @default.
• W2008409819 cites W2144111358 @default.
• W2008409819 cites W2144198294 @default.
• W2008409819 cites W2147511779 @default.
• W2008409819 cites W2152624886 @default.
• W2008409819 cites W2152685704 @default.
• W2008409819 cites W2157693529 @default.
• W2008409819 cites W2158201714 @default.
• W2008409819 cites W2162082382 @default.
• W2008409819 cites W2164691388 @default.
• W2008409819 cites W2166680118 @default.
• W2008409819 cites W2181131337 @default.
• W2008409819 cites W2303212700 @default.

• next