Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008424709> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2008424709 endingPage "738" @default.
- W2008424709 startingPage "731" @default.
- W2008424709 abstract "GTP-cyclohydrolase II (GCH II) encoded by RIB1 gene catalyzes the first committed step in the riboflavin biosynthetic pathway. We report here the cloning and characterization of the entire RIB1 ORF (EaRIB1) of 942 bp by reverse transcription polymerase chain reaction (RT-PCR) and rapid amplification of cDNA ends (RACE-PCR) in Eremothecium ashbyi where it was found to be present as a single-copy gene. EaRIB1 sequence is available at the GenBank Accession Number EF565374. The putative peptide of 313-aa has a high similarity of 60–70 % with GCH II sequences from other ascomycete fungi. Gene expression and alignment studies confirmed the functional annotation of this gene. Homology model was developed with Escherichia coli (PDB 2BZ1) as template to identify the catalytic domains and to explore its functional architecture. We report here the first three-dimensional model of any fungal GCH II which due to its absence in humans assumes significance for anti-fungal drug targeting." @default.
- W2008424709 created "2016-06-24" @default.
- W2008424709 creator A5006176226 @default.
- W2008424709 creator A5091573956 @default.
- W2008424709 date "2010-09-01" @default.
- W2008424709 modified "2023-09-23" @default.
- W2008424709 title "Molecular and structural characterization of GTP-cyclohydrolase II in Eremothecium ashbyi NRRL Y-1363: cDNA cloning, comparative sequence analysis and molecular modeling" @default.
- W2008424709 cites W1494555596 @default.
- W2008424709 cites W1522340786 @default.
- W2008424709 cites W1844536398 @default.
- W2008424709 cites W1847805250 @default.
- W2008424709 cites W1986191025 @default.
- W2008424709 cites W2003676968 @default.
- W2008424709 cites W2004412171 @default.
- W2008424709 cites W2015732160 @default.
- W2008424709 cites W2018278567 @default.
- W2008424709 cites W2040458097 @default.
- W2008424709 cites W2055043387 @default.
- W2008424709 cites W2063450941 @default.
- W2008424709 cites W2072499238 @default.
- W2008424709 cites W2075916846 @default.
- W2008424709 cites W2097642323 @default.
- W2008424709 cites W2112156003 @default.
- W2008424709 cites W2112244637 @default.
- W2008424709 cites W2114520383 @default.
- W2008424709 cites W2157829352 @default.
- W2008424709 doi "https://doi.org/10.1016/j.funbio.2010.06.006" @default.
- W2008424709 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20943182" @default.
- W2008424709 hasPublicationYear "2010" @default.
- W2008424709 type Work @default.
- W2008424709 sameAs 2008424709 @default.
- W2008424709 citedByCount "4" @default.
- W2008424709 countsByYear W20084247092012 @default.
- W2008424709 countsByYear W20084247092013 @default.
- W2008424709 crossrefType "journal-article" @default.
- W2008424709 hasAuthorship W2008424709A5006176226 @default.
- W2008424709 hasAuthorship W2008424709A5091573956 @default.
- W2008424709 hasConcept C104317684 @default.
- W2008424709 hasConcept C121050878 @default.
- W2008424709 hasConcept C15190224 @default.
- W2008424709 hasConcept C153911025 @default.
- W2008424709 hasConcept C165525559 @default.
- W2008424709 hasConcept C169627665 @default.
- W2008424709 hasConcept C181199279 @default.
- W2008424709 hasConcept C187882448 @default.
- W2008424709 hasConcept C19924922 @default.
- W2008424709 hasConcept C199360897 @default.
- W2008424709 hasConcept C41008148 @default.
- W2008424709 hasConcept C50724178 @default.
- W2008424709 hasConcept C54355233 @default.
- W2008424709 hasConcept C55493867 @default.
- W2008424709 hasConcept C79029880 @default.
- W2008424709 hasConcept C86803240 @default.
- W2008424709 hasConceptScore W2008424709C104317684 @default.
- W2008424709 hasConceptScore W2008424709C121050878 @default.
- W2008424709 hasConceptScore W2008424709C15190224 @default.
- W2008424709 hasConceptScore W2008424709C153911025 @default.
- W2008424709 hasConceptScore W2008424709C165525559 @default.
- W2008424709 hasConceptScore W2008424709C169627665 @default.
- W2008424709 hasConceptScore W2008424709C181199279 @default.
- W2008424709 hasConceptScore W2008424709C187882448 @default.
- W2008424709 hasConceptScore W2008424709C19924922 @default.
- W2008424709 hasConceptScore W2008424709C199360897 @default.
- W2008424709 hasConceptScore W2008424709C41008148 @default.
- W2008424709 hasConceptScore W2008424709C50724178 @default.
- W2008424709 hasConceptScore W2008424709C54355233 @default.
- W2008424709 hasConceptScore W2008424709C55493867 @default.
- W2008424709 hasConceptScore W2008424709C79029880 @default.
- W2008424709 hasConceptScore W2008424709C86803240 @default.
- W2008424709 hasIssue "9" @default.
- W2008424709 hasLocation W20084247091 @default.
- W2008424709 hasLocation W20084247092 @default.
- W2008424709 hasOpenAccess W2008424709 @default.
- W2008424709 hasPrimaryLocation W20084247091 @default.
- W2008424709 hasRelatedWork W2010333756 @default.
- W2008424709 hasRelatedWork W2100977637 @default.
- W2008424709 hasRelatedWork W2356585268 @default.
- W2008424709 hasRelatedWork W2359431220 @default.
- W2008424709 hasRelatedWork W2364221357 @default.
- W2008424709 hasRelatedWork W2376988106 @default.
- W2008424709 hasRelatedWork W2382315284 @default.
- W2008424709 hasRelatedWork W2386192280 @default.
- W2008424709 hasRelatedWork W2393892301 @default.
- W2008424709 hasRelatedWork W3031013641 @default.
- W2008424709 hasVolume "114" @default.
- W2008424709 isParatext "false" @default.
- W2008424709 isRetracted "false" @default.
- W2008424709 magId "2008424709" @default.
- W2008424709 workType "article" @default.