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- W2008430045 abstract "<h2>ABSTRACT</h2><h3>Objective</h3> To present a case of concomitant secretion of cortisol, androgens, and 11-deoxycorticosterone (DOC) by an adrenocortical carcinoma and review the literature in an attempt to identify similar cases. <h3>Methods</h3> The patient's medical history, physical examination, laboratory data, computed tomographic scan, and histopathologic results were analyzed and summarized in a case report, and an extensive review of the literature was performed. <h3>Results</h3> Endocrinologic data showed excess cortisol production, substantially elevated testosterone and androstenedione levels, and profoundly increased DOC in the setting of suppressed aldosterone. An abdominal computed tomographic scan showed a left adrenal tumor. A left adrenalectomy was performed, and the histopathologic diagnosis was stage II adrenocortical carcinoma. The review of the pertinent literature revealed the absence of any identical cases in the past. <h3>Conclusion</h3> Our patient presented with a rare case of cosecretion of cortisol, testosterone, androstenedione, and DOC by an adrenocortical carcinoma, resulting in a clinical picture consistent with Cushing's syndrome, hyperandrogenism, and primary hypermineralocorticoidism. We recommend the routine performance of a DOC assay in the setting of mineralocorticoid excess in association with low plasma aldosterone levels. <b>(Endocr Pract. 2007;13: 408-412)</b>" @default.
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- W2008430045 date "2007-07-01" @default.
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- W2008430045 title "Concomitant Secretion of Glucocorticoid, Androgens, and Mineralocorticoid by an Adrenocortical Carcinoma: Case Report and Review of Literature" @default.
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- W2008430045 doi "https://doi.org/10.4158/ep.13.4.408" @default.
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