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- W2008430410 abstract "Cajal bodies are small nuclear organelles with a number of nuclear functions. Here we show that FLICE-associated huge protein (FLASH), originally described as a component of the apoptosis signaling pathway, is mainly localized in Cajal bodies and is essential for their structure. Reduction in FLASH expression by short hairpin RNA results in disruption of the normal architecture of the Cajal body and relocalization of its components. Because the function of FLASH in the apoptosis receptor signaling pathway has been strongly questioned, we have now identified a clear function for this protein." @default.
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- W2008430410 date "2006-10-03" @default.
- W2008430410 modified "2023-09-25" @default.
- W2008430410 title "FLASH is an essential component of Cajal bodies" @default.
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- W2008430410 doi "https://doi.org/10.1073/pnas.0604225103" @default.
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