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- W2008431386 abstract "The c-Myc oncoprotein has previously been shown to associate with transcription regulator YY1 and to inhibit its activity. We show herein that endogenous c-Myc and YY1 associate in vivo and that changes in c-Myc levels, which accompany mitogenic stimulation or differentiation of cultured cells, affect the ratio of free to c-Myc-associated YY1. We have also investigated the mechanism by which association with c-Myc inhibits YY1's ability to regulate transcription. c-Myc does not block binding of YY1 to DNA. However, protein association studies suggest that c-Myc interferes with the ability of YY1 to contact basal transcription proteins TATA-binding protein and TFIIB." @default.
- W2008431386 created "2016-06-24" @default.
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- W2008431386 date "1996-10-01" @default.
- W2008431386 modified "2023-09-27" @default.
- W2008431386 title "YY1 and c-Myc associate in vivo in a manner that depends on c-Myc levels." @default.
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- W2008431386 doi "https://doi.org/10.1073/pnas.93.20.10638" @default.
- W2008431386 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/38206" @default.
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