FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008445315> ?p ?o ?g. }

• W2008445315 endingPage "3434" @default.
• W2008445315 startingPage "3417" @default.
• W2008445315 abstract "Several lines of evidence attest to the existence of alternative ligand binding sites on the oestrogen receptor (ER), including non-competitive inhibition by trilostane or tamoxifen. It is possible that the inhibitory action of conventional oestrogen agonists at high concentrations may indicate that they too interact at alternative ER sites, albeit at low affinity. To test this possibility an oestrogen reporter assay was used to compare the activity of different oestrogens and antagonists in breast cancer and prostate cell lines. All four cell lines tested contained different amounts of oestrogen receptor α (ERα), ERβ, progesterone receptor and coregulator mRNA. Though differences were observed in response to stimulation and inhibition, these correlated only with the presence or absence of ERα, and not with the other components. Thus stimulation of the reporter by oestradiol and oestrone was biphasic in the breast cancer cells, while prostate cells were unable to respond. Only T47D cells were stimulated by oestriol or diethylstilboestrol, however reporter activity of all the cell lines was repressed by 10mM diethylstilboestrol. Reporter activity of MCF-7 cells was inhibited by tamoxifen, raloxifene and ICI 182,780, but stimulated by trilostane, yet all these antioestrogens inhibited agonist-stimulated activity. Trilostane also inhibited the agonism seen in cells co-treated with E2 and tamoxifen. It is clear that several of the compounds tested may have either agonist or antagonist effects under different conditions and at different concentrations, acting through ERα alone. Though biphasic dose response curves, or hormesis, have been attributed to various mechanisms, we here provide evidence that alternative ligand binding sites may contribute to this phenomenon." @default.
• W2008445315 created "2016-06-24" @default.
• W2008445315 creator A5019087731 @default.
• W2008445315 creator A5026994422 @default.
• W2008445315 creator A5048528745 @default.
• W2008445315 creator A5055998813 @default.
• W2008445315 creator A5090058262 @default.
• W2008445315 date "2010-10-29" @default.
• W2008445315 modified "2023-09-26" @default.
• W2008445315 title "Multiple Routes to Oestrogen Antagonism" @default.
• W2008445315 cites W1497395693 @default.
• W2008445315 cites W1538903611 @default.
• W2008445315 cites W1562960938 @default.
• W2008445315 cites W1966428567 @default.
• W2008445315 cites W1968954802 @default.
• W2008445315 cites W1970066136 @default.
• W2008445315 cites W1979323054 @default.
• W2008445315 cites W1980977242 @default.
• W2008445315 cites W1991455388 @default.
• W2008445315 cites W2002021255 @default.
• W2008445315 cites W2003027153 @default.
• W2008445315 cites W2008986529 @default.
• W2008445315 cites W2012471950 @default.
• W2008445315 cites W2013145602 @default.
• W2008445315 cites W2015491422 @default.
• W2008445315 cites W2017347334 @default.
• W2008445315 cites W2021949997 @default.
• W2008445315 cites W2023314887 @default.
• W2008445315 cites W2023405117 @default.
• W2008445315 cites W2030669256 @default.
• W2008445315 cites W2033616764 @default.
• W2008445315 cites W2034640494 @default.
• W2008445315 cites W2035960483 @default.
• W2008445315 cites W2039871782 @default.
• W2008445315 cites W2045458292 @default.
• W2008445315 cites W2049970571 @default.
• W2008445315 cites W2051676088 @default.
• W2008445315 cites W2056155028 @default.
• W2008445315 cites W2056806829 @default.
• W2008445315 cites W2059874017 @default.
• W2008445315 cites W2062330662 @default.
• W2008445315 cites W2067642579 @default.
• W2008445315 cites W2068076267 @default.
• W2008445315 cites W2070338654 @default.
• W2008445315 cites W2074579082 @default.
• W2008445315 cites W2079149091 @default.
• W2008445315 cites W2082044237 @default.
• W2008445315 cites W2082833775 @default.
• W2008445315 cites W2083016691 @default.
• W2008445315 cites W2090428300 @default.
• W2008445315 cites W2096576358 @default.
• W2008445315 cites W2101237904 @default.
• W2008445315 cites W2101738855 @default.
• W2008445315 cites W2102564453 @default.
• W2008445315 cites W2104139848 @default.
• W2008445315 cites W2104654854 @default.
• W2008445315 cites W2106324853 @default.
• W2008445315 cites W2111650618 @default.
• W2008445315 cites W2116325136 @default.
• W2008445315 cites W2121454015 @default.
• W2008445315 cites W2124115522 @default.
• W2008445315 cites W2141544063 @default.
• W2008445315 cites W2147255658 @default.
• W2008445315 cites W2150634831 @default.
• W2008445315 cites W2151888740 @default.
• W2008445315 cites W2157569053 @default.
• W2008445315 cites W2161106457 @default.
• W2008445315 cites W2166760402 @default.
• W2008445315 cites W225023543 @default.
• W2008445315 cites W3162684029 @default.
• W2008445315 cites W4246405622 @default.
• W2008445315 cites W4317563799 @default.
• W2008445315 cites W5132381 @default.
• W2008445315 doi "https://doi.org/10.3390/ph3113417" @default.
• W2008445315 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4034074" @default.
• W2008445315 hasPublicationYear "2010" @default.
• W2008445315 type Work @default.
• W2008445315 sameAs 2008445315 @default.
• W2008445315 citedByCount "2" @default.
• W2008445315 countsByYear W20084453152014 @default.
• W2008445315 countsByYear W20084453152021 @default.
• W2008445315 crossrefType "journal-article" @default.
• W2008445315 hasAuthorship W2008445315A5019087731 @default.
• W2008445315 hasAuthorship W2008445315A5026994422 @default.
• W2008445315 hasAuthorship W2008445315A5048528745 @default.
• W2008445315 hasAuthorship W2008445315A5055998813 @default.
• W2008445315 hasAuthorship W2008445315A5090058262 @default.
• W2008445315 hasBestOaLocation W20084453151 @default.
• W2008445315 hasConcept C104317684 @default.
• W2008445315 hasConcept C121608353 @default.
• W2008445315 hasConcept C126322002 @default.
• W2008445315 hasConcept C134018914 @default.
• W2008445315 hasConcept C150194340 @default.
• W2008445315 hasConcept C161733203 @default.
• W2008445315 hasConcept C170493617 @default.
• W2008445315 hasConcept C185592680 @default.
• W2008445315 hasConcept C24998067 @default.
• W2008445315 hasConcept C2777176818 @default.

• next