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- W2008447022 abstract "The effects of levamisole (LT), dexamisole (DT), levo-p-bromotetramisole (LBT) and dextro-p-bromotetramisole (DBT) on bone were examined in an organ culture system using calvarial bones from newborn mice. LBT and DBT at concentrations inhibitory effect on mineral mobilization and matrix degradation. LBT, DBT (100 and 300 μM) as well as LT and DT (⩾ 100 μM) reduced the spontaneous release of β-glucuronidase without having any marked effect on the release of lactate dehydrogenase (LDH). LT and DT did not influence protein synthesis but LBT and DBT were inhibitory in concentrations at and above 100 μM. Mitotic activity, as assessed by incorporation of [3H]thymaline, was inhibited by LBT and DBT (0.1, 1 mM). LT and LBT caused a stereospecific inhibition of GPase, PPiase and ATPase. It is concluded that tetramisoles are potent, non-stereospecific inhibitors of bone resorption in vitro." @default.
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- W2008447022 date "1984-10-01" @default.
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- W2008447022 title "Effect of levamisole on bone resorption in cultured mouse calvaria" @default.
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- W2008447022 doi "https://doi.org/10.1016/0014-2999(84)90643-5" @default.
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