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- W2008450994 abstract "Male Wistar rats received intrahippocampal injections of 3 nmol aggregated Aβ (25–35), intracerebroventricular injections of 0.5 μg human recombinant TNFα or both. Aβ or Aβ + TNFα (but not TNFα alone) induced cell loss in the CA1 pyramidal cell layer, the extension of neuronal degeneration being significantly larger in Aβ + TNFα-treated group. In hippocampi of both Aβ-treated groups (but not in TNFα alone-treated group) reactive gliosis and microglia activation (upregulation of GFAP and isolectin B4 expression) were demonstrated. TUNEL-positive nuclei were found in the hippocampi of both Aβ-treated groups. Caspase-3 activity significantly increased in the ipsilateral hippocampus after the injection of Aβ. However, TNFα prevented Aβ-induced caspase-3 activation. The results are discussed from the perspective of dual (neuroprotective and neurodestructive) roles of TNF in the brain.Acknowledgement: Supported by RBR F (grant # 01-04-449477)." @default.
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- W2008450994 date "2003-05-08" @default.
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- W2008450994 title "Tumor necrosis factor-alpha aggravates hippocampal damage in rat induced by amyloid beta-peptide (25-35)" @default.
- W2008450994 doi "https://doi.org/10.1046/j.1471-4159.85.s2.16_6.x" @default.
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