FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008451121> ?p ?o ?g. }

• W2008451121 abstract "The AMP-activated protein kinase (AMPK) regulates metabolism in normal and pathological conditions and responds to nutrients, hormones, anti-diabetic drugs and physical exercise. AMPK is activated by the kinase LKB1 and inactivated by phosphatases whose identities remain uncertain. Here we show that AMPK associates with α-SNAP, an adapter that enables disassembly of cis-SNARE complexes formed during membrane fusion. Knockdown of α-SNAP activates AMPK to phosphorylate its endogenous substrates acetyl CoA carboxylase and Raptor, and provokes mitochondrial biogenesis. AMPK phosphorylation is rescued from α-SNAP RNA interference by LKB1 knockdown or expression of wild-type but not mutated α-SNAP. Recombinant wild-type but not mutated α-SNAP dephosphorylates pThr172 in AMPKα in vitro. Overexpression of wild-type but not mutated α-SNAP prevents AMPK activation in cells treated with agents to elevate AMP concentration. The mouse α-SNAP mutant hyh (hydrocephalus with hop gait) shows enhanced binding and inhibition of AMPK. By negatively controlling AMPK, α-SNAP therefore potentially coordinates membrane trafficking and metabolism. The energy-sensing kinase AMPK is regulated by phosphorylation, however, the identity of AMPK phosphatases remains uncertain. Here the authors show that α-SNAP, a protein previously known for its role in membrane fusion, can dephosphorylate AMPK despite lacking a recognizable phosphatase domain." @default.
• W2008451121 created "2016-06-24" @default.
• W2008451121 creator A5074981380 @default.
• W2008451121 creator A5076449077 @default.
• W2008451121 date "2013-03-05" @default.
• W2008451121 modified "2023-09-27" @default.
• W2008451121 title "α-SNAP inhibits AMPK signaling to reduce mitochondrial biogenesis and dephosphorylates Thr172 in AMPKα in vitro" @default.
• W2008451121 cites W1504436115 @default.
• W2008451121 cites W1603357096 @default.
• W2008451121 cites W1965885099 @default.
• W2008451121 cites W1971016259 @default.
• W2008451121 cites W1978763812 @default.
• W2008451121 cites W1989170134 @default.
• W2008451121 cites W1990278643 @default.
• W2008451121 cites W2000302106 @default.
• W2008451121 cites W2022630818 @default.
• W2008451121 cites W2025582729 @default.
• W2008451121 cites W2036221207 @default.
• W2008451121 cites W2050427373 @default.
• W2008451121 cites W2055579594 @default.
• W2008451121 cites W2065935014 @default.
• W2008451121 cites W2070910260 @default.
• W2008451121 cites W2073181999 @default.
• W2008451121 cites W2074600198 @default.
• W2008451121 cites W2080107084 @default.
• W2008451121 cites W2081920342 @default.
• W2008451121 cites W2115118001 @default.
• W2008451121 cites W2117181594 @default.
• W2008451121 cites W2121134070 @default.
• W2008451121 cites W2125417922 @default.
• W2008451121 cites W2126599747 @default.
• W2008451121 cites W2132495676 @default.
• W2008451121 cites W2133444149 @default.
• W2008451121 cites W2150541721 @default.
• W2008451121 cites W2150551377 @default.
• W2008451121 cites W2159620999 @default.
• W2008451121 cites W2160615487 @default.
• W2008451121 doi "https://doi.org/10.1038/ncomms2565" @default.
• W2008451121 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3595137" @default.
• W2008451121 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23463002" @default.
• W2008451121 hasPublicationYear "2013" @default.
• W2008451121 type Work @default.
• W2008451121 sameAs 2008451121 @default.
• W2008451121 citedByCount "33" @default.
• W2008451121 countsByYear W20084511212014 @default.
• W2008451121 countsByYear W20084511212015 @default.
• W2008451121 countsByYear W20084511212016 @default.
• W2008451121 countsByYear W20084511212017 @default.
• W2008451121 countsByYear W20084511212019 @default.
• W2008451121 countsByYear W20084511212020 @default.
• W2008451121 countsByYear W20084511212021 @default.
• W2008451121 countsByYear W20084511212022 @default.
• W2008451121 countsByYear W20084511212023 @default.
• W2008451121 crossrefType "journal-article" @default.
• W2008451121 hasAuthorship W2008451121A5074981380 @default.
• W2008451121 hasAuthorship W2008451121A5076449077 @default.
• W2008451121 hasBestOaLocation W20084511211 @default.
• W2008451121 hasConcept C11960822 @default.
• W2008451121 hasConcept C170493617 @default.
• W2008451121 hasConcept C180526460 @default.
• W2008451121 hasConcept C184235292 @default.
• W2008451121 hasConcept C185592680 @default.
• W2008451121 hasConcept C2776780712 @default.
• W2008451121 hasConcept C2777229759 @default.
• W2008451121 hasConcept C2780124434 @default.
• W2008451121 hasConcept C28859421 @default.
• W2008451121 hasConcept C55493867 @default.
• W2008451121 hasConcept C86803240 @default.
• W2008451121 hasConcept C95444343 @default.
• W2008451121 hasConcept C97029542 @default.
• W2008451121 hasConceptScore W2008451121C11960822 @default.
• W2008451121 hasConceptScore W2008451121C170493617 @default.
• W2008451121 hasConceptScore W2008451121C180526460 @default.
• W2008451121 hasConceptScore W2008451121C184235292 @default.
• W2008451121 hasConceptScore W2008451121C185592680 @default.
• W2008451121 hasConceptScore W2008451121C2776780712 @default.
• W2008451121 hasConceptScore W2008451121C2777229759 @default.
• W2008451121 hasConceptScore W2008451121C2780124434 @default.
• W2008451121 hasConceptScore W2008451121C28859421 @default.
• W2008451121 hasConceptScore W2008451121C55493867 @default.
• W2008451121 hasConceptScore W2008451121C86803240 @default.
• W2008451121 hasConceptScore W2008451121C95444343 @default.
• W2008451121 hasConceptScore W2008451121C97029542 @default.
• W2008451121 hasIssue "1" @default.
• W2008451121 hasLocation W20084511211 @default.
• W2008451121 hasLocation W20084511212 @default.
• W2008451121 hasLocation W20084511213 @default.
• W2008451121 hasLocation W20084511214 @default.
• W2008451121 hasOpenAccess W2008451121 @default.
• W2008451121 hasPrimaryLocation W20084511211 @default.
• W2008451121 hasRelatedWork W2017342497 @default.
• W2008451121 hasRelatedWork W2022630818 @default.
• W2008451121 hasRelatedWork W2024480783 @default.
• W2008451121 hasRelatedWork W2031315554 @default.
• W2008451121 hasRelatedWork W2041514707 @default.
• W2008451121 hasRelatedWork W2058093835 @default.
• W2008451121 hasRelatedWork W2080107084 @default.
• W2008451121 hasRelatedWork W2109693559 @default.
• W2008451121 hasRelatedWork W2503094451 @default.
• W2008451121 hasRelatedWork W2770372222 @default.

• next