Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008454077> ?p ?o ?g. }
- W2008454077 abstract "Significance Gene duplication is prominent among evolutionary pathways through which novel transcription factors and gene regulatory networks evolve. A model in mammals is provided by Sry, a Y-encoded Sox factor that initiates male development. We provide evidence that a CAG DNA microsatellite invasion into the Sry gene of a rodent superfamily enabled its rapid evolution. This unstable microsatellite encodes a variable length glutamine-rich repeat domain. Our results suggest that intragenic complementation between the glutamine-rich domain and canonical Sry motifs accelerated their divergence through repeat length–dependent biochemical linkages. Such novelty may underlie emergence of non–Sry-dependent mechanisms of male sex determination." @default.
- W2008454077 created "2016-06-24" @default.
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- W2008454077 date "2013-07-30" @default.
- W2008454077 modified "2023-10-16" @default.
- W2008454077 title "Microsatellite-encoded domain in rodent Sry functions as a genetic capacitor to enable the rapid evolution of biological novelty" @default.
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- W2008454077 doi "https://doi.org/10.1073/pnas.1300860110" @default.
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