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• W2008454529 abstract "White adipose tissue (WAT) regulates energy metabolism by secretion of proteins with endocrine and paracrine effects. Dysregulation of the secretome of obesity-associated enlarged WAT may lead to obesity-related disorders. This can be caused by hypoxia as a result of poorly vascularized WAT. The effect of hypoxia on the secretome of human (pre)adipocytes is largely unknown. Therefore, we investigated the effect of CoCl2, a hypoxia mimetic, on the secretome of human SGBS (pre)adipocytes by a proteomics approach combined with bioinformatic analysis. In addition, regulation of protein secretion was examined by protein turnover experiments. As such, secretome changes were particularly associated with protein down-regulation and extracellular matrix protein dysregulation. The observed up-regulation of collagens in adipocytes may be essential for cell survival while down-regulation of collagens in preadipocytes may indicate a disturbed differentiation process. These CoCl2-induced changes reflect WAT dysfunction that ultimately may lead to obesity-associated complications. In addition, 9 novel adipocyte secreted proteins were identified from which 6 were regulated by CoCl2. Mass spectrometry data have been deposited to the ProteomeXchange with identifier PXD000162." @default.
• W2008454529 created "2016-06-24" @default.
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• W2008454529 date "2013-12-01" @default.
• W2008454529 modified "2023-10-07" @default.
• W2008454529 title "Hypoxia-mimetic effects in the secretome of human preadipocytes and adipocytes" @default.
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• W2008454529 doi "https://doi.org/10.1016/j.bbapap.2013.10.003" @default.
• W2008454529 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24140569" @default.
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