FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008455557> ?p ?o ?g. }

• W2008455557 endingPage "187" @default.
• W2008455557 startingPage "183" @default.
• W2008455557 abstract "Background In children with cystic fibrosis (CF), tobramycin concentrations are monitored via the area under the plasma concentration time curve (AUC) approach. Currently, a minimum of 2 plasma concentrations of tobramycin within one dosing interval are required to estimate the AUC, which is costly, painful and blood collection is often difficult to coordinate. Aim To evaluate the accuracy of tobramycin AUC estimated using 1 plasma concentration compared to AUC based on 2 plasma concentrations calculated using Bayesian software. Method Data were collected from paediatric patients with CF prescribed once daily intravenous tobramycin. Each patient had 2 blood samples taken within a dosing interval (according to usual practice at the hospital) on 2 separate occasions during their admission. Data on tobramycin dosing and concentration, and patient demographics from the first occasion were entered into the Bayesian software, TCIWorks, to establish an individual patient's pharmacokinetic model. Data from the second occasion were then also entered into TCIWorks to estimate 2 AUCs – from 1 (AUC1) and 2 (AUC2) plasma concentrations. The accuracy of each patient's AUCs (AUC1 and AUC2) were then evaluated using a Bland-Altman analysis to describe bias relative to the mean of the two values. To show the benefits of good quality data when using TCIWorks, data were obtained and analysed from 2 patient groups. For group A patients, accurate sampling and administration times of the tobramycin infusion were obtained prospectively. Group B consisted of patients from group A plus additional patients who had data collected from a retrospective medical chart review. Results Data were collected for 30 paediatric patients with CF − 14 in group A and 16 additional patients in group B. In group A, there was no significant bias relative to the mean of the values for AUC1 and AUC2 (mean bias 1; 95%CI −4.9–6.9). A similar result was seen in group B (mean bias −0.7; 95%CI −10–8.6) indicating that the 2 estimates of tobramycin AUC (using 1 and 2 blood samples) are not significantly different. Conclusion: Once an individual paediatric patient's tobramycin pharmacokinetic model is determined with two blood samples using TCIWorks, only one blood sample is required to estimate an AUC for tobramycin." @default.
• W2008455557 created "2016-06-24" @default.
• W2008455557 creator A5003952300 @default.
• W2008455557 creator A5006922006 @default.
• W2008455557 creator A5012500496 @default.
• W2008455557 creator A5044361235 @default.
• W2008455557 creator A5069042090 @default.
• W2008455557 creator A5074063229 @default.
• W2008455557 creator A5078445435 @default.
• W2008455557 creator A5088542927 @default.
• W2008455557 date "2011-09-01" @default.
• W2008455557 modified "2023-09-27" @default.
• W2008455557 title "Bayesian Optimisation of Tobramycin Dosing in Paediatric Patients with Cystic Fibrosis" @default.
• W2008455557 cites W1838411867 @default.
• W2008455557 cites W1920192551 @default.
• W2008455557 cites W1965409354 @default.
• W2008455557 cites W1976544500 @default.
• W2008455557 cites W1992266226 @default.
• W2008455557 cites W2019256505 @default.
• W2008455557 cites W2029854762 @default.
• W2008455557 cites W2033379900 @default.
• W2008455557 cites W2037847203 @default.
• W2008455557 cites W2039121822 @default.
• W2008455557 cites W2039740101 @default.
• W2008455557 cites W2071277317 @default.
• W2008455557 cites W2073958994 @default.
• W2008455557 cites W2098489891 @default.
• W2008455557 cites W2105915947 @default.
• W2008455557 cites W2110961503 @default.
• W2008455557 cites W2139226586 @default.
• W2008455557 cites W2140801627 @default.
• W2008455557 cites W2142191352 @default.
• W2008455557 cites W2143692728 @default.
• W2008455557 cites W2155069031 @default.
• W2008455557 cites W2168278988 @default.
• W2008455557 cites W2243709209 @default.
• W2008455557 doi "https://doi.org/10.1002/j.2055-2335.2011.tb00857.x" @default.
• W2008455557 hasPublicationYear "2011" @default.
• W2008455557 type Work @default.
• W2008455557 sameAs 2008455557 @default.
• W2008455557 citedByCount "5" @default.
• W2008455557 countsByYear W20084555572012 @default.
• W2008455557 countsByYear W20084555572014 @default.
• W2008455557 countsByYear W20084555572016 @default.
• W2008455557 countsByYear W20084555572018 @default.
• W2008455557 countsByYear W20084555572022 @default.
• W2008455557 crossrefType "journal-article" @default.
• W2008455557 hasAuthorship W2008455557A5003952300 @default.
• W2008455557 hasAuthorship W2008455557A5006922006 @default.
• W2008455557 hasAuthorship W2008455557A5012500496 @default.
• W2008455557 hasAuthorship W2008455557A5044361235 @default.
• W2008455557 hasAuthorship W2008455557A5069042090 @default.
• W2008455557 hasAuthorship W2008455557A5074063229 @default.
• W2008455557 hasAuthorship W2008455557A5078445435 @default.
• W2008455557 hasAuthorship W2008455557A5088542927 @default.
• W2008455557 hasBestOaLocation W20084555572 @default.
• W2008455557 hasConcept C112705442 @default.
• W2008455557 hasConcept C126322002 @default.
• W2008455557 hasConcept C141071460 @default.
• W2008455557 hasConcept C144024400 @default.
• W2008455557 hasConcept C149923435 @default.
• W2008455557 hasConcept C2775832221 @default.
• W2008455557 hasConcept C2776938444 @default.
• W2008455557 hasConcept C2777288759 @default.
• W2008455557 hasConcept C2778974779 @default.
• W2008455557 hasConcept C2780084366 @default.
• W2008455557 hasConcept C2988731192 @default.
• W2008455557 hasConcept C44249647 @default.
• W2008455557 hasConcept C501593827 @default.
• W2008455557 hasConcept C71924100 @default.
• W2008455557 hasConcept C76318530 @default.
• W2008455557 hasConcept C86803240 @default.
• W2008455557 hasConcept C89423630 @default.
• W2008455557 hasConceptScore W2008455557C112705442 @default.
• W2008455557 hasConceptScore W2008455557C126322002 @default.
• W2008455557 hasConceptScore W2008455557C141071460 @default.
• W2008455557 hasConceptScore W2008455557C144024400 @default.
• W2008455557 hasConceptScore W2008455557C149923435 @default.
• W2008455557 hasConceptScore W2008455557C2775832221 @default.
• W2008455557 hasConceptScore W2008455557C2776938444 @default.
• W2008455557 hasConceptScore W2008455557C2777288759 @default.
• W2008455557 hasConceptScore W2008455557C2778974779 @default.
• W2008455557 hasConceptScore W2008455557C2780084366 @default.
• W2008455557 hasConceptScore W2008455557C2988731192 @default.
• W2008455557 hasConceptScore W2008455557C44249647 @default.
• W2008455557 hasConceptScore W2008455557C501593827 @default.
• W2008455557 hasConceptScore W2008455557C71924100 @default.
• W2008455557 hasConceptScore W2008455557C76318530 @default.
• W2008455557 hasConceptScore W2008455557C86803240 @default.
• W2008455557 hasConceptScore W2008455557C89423630 @default.
• W2008455557 hasIssue "3" @default.
• W2008455557 hasLocation W20084555571 @default.
• W2008455557 hasLocation W20084555572 @default.
• W2008455557 hasOpenAccess W2008455557 @default.
• W2008455557 hasPrimaryLocation W20084555571 @default.
• W2008455557 hasRelatedWork W1997848646 @default.
• W2008455557 hasRelatedWork W2008455557 @default.
• W2008455557 hasRelatedWork W2051036097 @default.

• next