FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008455715> ?p ?o ?g. }

• W2008455715 endingPage "154" @default.
• W2008455715 startingPage "139" @default.
• W2008455715 abstract "The mechanisms mediating the effects of thyrotropin-releasing hormone (TRH) on the cardiovascular system were studied in the conscious rat. Intracerebroventricular (i.c.v.) injection of TRH (8 pmol-80 nmol/kg) induced dose-dependent increases in mean arterial pressure, heart rate, and cardiac index. Hindquarter blood flow increased due to vasodilation, while an increase in renal and mesenteric vascular resistance caused a decrease in blood flow in the respective organs. The plasma levels of norepinephrine and epinephrine were increased by TRH, while there was no change in plasma renin activity or vasopressin. The cardiovascular actions of i.c.v. TRH were not influenced by blockade of the renin-angiotensin system or vasopressin receptors. The ganglion blocker chlorisondamine and the alpha 1- and alpha 2-adrenoreceptor antagonist phentolamine (2 mg/kg i.v.) abolished the increase in blood pressure and mesenteric vasoconstriction after i.c.v. TRH. Propranolol (2 mg/kg i.v.) blocked the TRH-induced increase in cardiac index, heart rate, and hindquarter blood flow. The hindquarter vasodilation induced by TRH was also blocked by the selective beta 2-adrenoceptor antagonist ICI 188,551 (1 or 2 mg/kg i.v.), while the beta 1-adrenoceptor blocker practolol (10 mg/kg i.v.) had no effect on the hindquarter vasodilation produced by TRH but totally blocked the increase in cardiac index. In adrenal demedullated rats, the systemic hemodynamic effects of i.c.v. TRH were diminished along with the decrease in renal blood flow and increase in renal vascular resistance; however, the increase in hindquarter blood flow was attenuated only in adrenal demedullated rats pretreated with the sympathetic blocker bretylium. The renal vasoconstriction induced by i.c.v. TRH was not abolished by renal denervation. In sinoaortic debuffered rats, the pressor, tachycardic, and mesenteric vasoconstrictor responses to centrally administered TRH were significantly potentiated. Taken together, these data suggest that the putative neurotransmitter TRH may play a role in central regulation of cardiac functions and organ blood flow distribution through both the sympathetic nerves and the adrenal medulla. A pivotal role for beta 2-adrenoceptors in mediation of hindquarter vasodilation is also demonstrated." @default.
• W2008455715 created "2016-06-24" @default.
• W2008455715 creator A5003026401 @default.
• W2008455715 creator A5051891351 @default.
• W2008455715 creator A5077914492 @default.
• W2008455715 date "1988-01-01" @default.
• W2008455715 modified "2023-10-06" @default.
• W2008455715 title "Hemodynamic and neural mechanisms of action of thyrotropin-releasing hormone in the rat." @default.
• W2008455715 cites W1547399881 @default.
• W2008455715 cites W1884488047 @default.
• W2008455715 cites W1965978945 @default.
• W2008455715 cites W1968296631 @default.
• W2008455715 cites W1975035985 @default.
• W2008455715 cites W1975985352 @default.
• W2008455715 cites W1976997467 @default.
• W2008455715 cites W1980254810 @default.
• W2008455715 cites W1980414255 @default.
• W2008455715 cites W1981980198 @default.
• W2008455715 cites W1986405090 @default.
• W2008455715 cites W1990068308 @default.
• W2008455715 cites W1998647420 @default.
• W2008455715 cites W2000621463 @default.
• W2008455715 cites W2003948456 @default.
• W2008455715 cites W2011296485 @default.
• W2008455715 cites W2016710770 @default.
• W2008455715 cites W2017522610 @default.
• W2008455715 cites W2027486355 @default.
• W2008455715 cites W2030700978 @default.
• W2008455715 cites W2037034421 @default.
• W2008455715 cites W2037805401 @default.
• W2008455715 cites W2044499498 @default.
• W2008455715 cites W2047439935 @default.
• W2008455715 cites W2052250637 @default.
• W2008455715 cites W2057514674 @default.
• W2008455715 cites W2091914421 @default.
• W2008455715 cites W2095388238 @default.
• W2008455715 cites W2099688352 @default.
• W2008455715 cites W2166377487 @default.
• W2008455715 cites W2169308829 @default.
• W2008455715 cites W2171260221 @default.
• W2008455715 cites W62761446 @default.
• W2008455715 doi "https://doi.org/10.1161/01.res.62.1.139" @default.
• W2008455715 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2891452" @default.
• W2008455715 hasPublicationYear "1988" @default.
• W2008455715 type Work @default.
• W2008455715 sameAs 2008455715 @default.
• W2008455715 citedByCount "46" @default.
• W2008455715 crossrefType "journal-article" @default.
• W2008455715 hasAuthorship W2008455715A5003026401 @default.
• W2008455715 hasAuthorship W2008455715A5051891351 @default.
• W2008455715 hasAuthorship W2008455715A5077914492 @default.
• W2008455715 hasBestOaLocation W20084557151 @default.
• W2008455715 hasConcept C120770815 @default.
• W2008455715 hasConcept C126322002 @default.
• W2008455715 hasConcept C134018914 @default.
• W2008455715 hasConcept C138976137 @default.
• W2008455715 hasConcept C142225936 @default.
• W2008455715 hasConcept C178853913 @default.
• W2008455715 hasConcept C185592680 @default.
• W2008455715 hasConcept C198710026 @default.
• W2008455715 hasConcept C2776370428 @default.
• W2008455715 hasConcept C2777012931 @default.
• W2008455715 hasConcept C2778151854 @default.
• W2008455715 hasConcept C2779961880 @default.
• W2008455715 hasConcept C2780253649 @default.
• W2008455715 hasConcept C2908929049 @default.
• W2008455715 hasConcept C58245268 @default.
• W2008455715 hasConcept C71924100 @default.
• W2008455715 hasConcept C84393581 @default.
• W2008455715 hasConceptScore W2008455715C120770815 @default.
• W2008455715 hasConceptScore W2008455715C126322002 @default.
• W2008455715 hasConceptScore W2008455715C134018914 @default.
• W2008455715 hasConceptScore W2008455715C138976137 @default.
• W2008455715 hasConceptScore W2008455715C142225936 @default.
• W2008455715 hasConceptScore W2008455715C178853913 @default.
• W2008455715 hasConceptScore W2008455715C185592680 @default.
• W2008455715 hasConceptScore W2008455715C198710026 @default.
• W2008455715 hasConceptScore W2008455715C2776370428 @default.
• W2008455715 hasConceptScore W2008455715C2777012931 @default.
• W2008455715 hasConceptScore W2008455715C2778151854 @default.
• W2008455715 hasConceptScore W2008455715C2779961880 @default.
• W2008455715 hasConceptScore W2008455715C2780253649 @default.
• W2008455715 hasConceptScore W2008455715C2908929049 @default.
• W2008455715 hasConceptScore W2008455715C58245268 @default.
• W2008455715 hasConceptScore W2008455715C71924100 @default.
• W2008455715 hasConceptScore W2008455715C84393581 @default.
• W2008455715 hasIssue "1" @default.
• W2008455715 hasLocation W20084557151 @default.
• W2008455715 hasLocation W20084557152 @default.
• W2008455715 hasLocation W20084557153 @default.
• W2008455715 hasOpenAccess W2008455715 @default.
• W2008455715 hasPrimaryLocation W20084557151 @default.
• W2008455715 hasRelatedWork W1887639437 @default.
• W2008455715 hasRelatedWork W1977123261 @default.
• W2008455715 hasRelatedWork W1992645942 @default.
• W2008455715 hasRelatedWork W2016647631 @default.
• W2008455715 hasRelatedWork W2021641980 @default.
• W2008455715 hasRelatedWork W2032943519 @default.

• next