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• W2008455891 abstract "<h3>Importance</h3> MEK inhibitors are being evaluated in clinical trials for treatment of different malignant neoplasms; trametinib dimethyl sulfoxide was approved by the US Food and Drug Administration for melanoma in 2013. We present 3 cases of patients receiving MEK inhibitors who developed an atypical eruption. <h3>Observations</h3> Three patients who were receiving different MEK inhibitors (selumetinib, cobimetinib, and trametinib) developed an eruption, all associated with unique duskiness. Drug hypersensitivity was confirmed by histopathologic testing in 2 of the 3 cases. The skin eruption responded well to corticosteroids and did not recur when treatment with the MEK inhibitor was restarted in 2 of the patients. <h3>Conclusions and Relevance</h3> The typical skin reaction associated with MEK inhibitors is a papulopustular eruption. To our knowledge, the dusky erythema that occurred in the 3 patients described here has not previously been reported for this drug class." @default.
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• W2008455891 date "2015-01-01" @default.
• W2008455891 modified "2023-09-24" @default.
• W2008455891 title "MEK Inhibitor–Induced Dusky Erythema" @default.
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• W2008455891 doi "https://doi.org/10.1001/jamadermatol.2014.3207" @default.
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