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- W2008459409 abstract "The lymphocyte-inhibiting factor extracted from the thymus (LIFT) is effective in decreasing several immune responses. The aim of this study was to determine whether LIFT is able to depress humoral immune reactions and if so, whether it acts on T lymphocytes, B lymphocytes, or both.Simultaneous administration of LIFT and antigen severely impairs the IgG antibody formation against dinitrophenylated human IgG (DNP-HGG(a highly T lymphocyte-dependent response) and, to a lesser extent, the IgM antibody formation against sheep red blood cells (a partly T lymphocyte-dependent response). In contrast, the IgM anti-DNP-polymerized flagellin response (which does not require T lymphocyte collaboration) is not depressed at all by such treatment. These results demonstrate a LIFT action specificity on T lymphocytes only, and strongly argue for the assimilation of LIFT with a T lymphocyte chalone. The existence of a lymphocyte-inhibiting factor specific for B lymphocytes, or B lymphocyte chalone, is discussed." @default.
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- W2008459409 date "1973-10-01" @default.
- W2008459409 modified "2023-10-14" @default.
- W2008459409 title "T lymphocyte specificity of a lymphocyte-inhibiting factor (chalone) extracted from the thymus" @default.
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- W2008459409 doi "https://doi.org/10.1002/eji.1830031006" @default.
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