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• W2008466251 abstract "Summary: Eighteen different fungi, reported to produce keratomycosis in man, were tested for their susceptibility to in vitro antifungal action of natamycin, econazole, ketoconazole and the results were compared with amphotericin B. None of the fungi viz. Alternaria, Aspergillus flavus, Asp. fumigatus, Asp. niger, Candida albicans, Curvularia, Diplosporium, Drechslera, Fusarium, Hormodendrum, Mucor, Penicillium, Paecilomyces, Rhizopus, Rhodotorula, Syncephalastrum, Trichoderma, and Verticillium were inhibited by 0.5–5.0 μg/ml of Natamycin, 13 were inhibited by 10 μg/ml and all except Asp. flavus were inhibited by 100 μg/ml. Econazole was able to arrest the growth of 7 fungi even at a concentration of 0.5 μg/ml. With 7.5 μg/ml, all but Rhodotorula failed to grow. Strengths from 10 to 100 μg/ml were inhibitory to all. However, only 100 μg/ml of ketoconazole could produce a similar effect; lower strengths being ineffective or effective against a few only. Amphotericin B was found to be the inferior most because even as high as 100 μg/ml of it, could inhibit only Asp. niger, Drechslera, Alternaria, Curvularia and Paecilomyces.Of the other indigenous herbs or chemicals tested for antifungal activity, garlic (2.5 to 50.0 μg/ml), neem (1.0 % aqueous and alcoholic extract of Margosa), Levamisole (0.1 to 1.0 μg/ml) were found totally ineffective. Disodium citrate salt of berberine was found to have an identical or even better antifungal action than berberine sulphate. Interestingly, yellow oxide of mercury was found to have a strong antifungal activity in concentrations from 2–10 μg/ml, comparable to other chemicals tested earlier. It is noteworthy that it also possessed some antibacterial action in strengths between 50–200 μg/ml. Repeated experiments yielded consistent findings.Zusammenfassung: Die in vitro-Aktivitat von Natamycin, Econazol, Ketoconazol und Amphotericin B wurde gegen 18 Pilze gepruft, die als Erreger einer Keratomykose beim Menschen bekannt sind. Keiner dieser Pilze (Alternaria sp., Aspergillus flavus, Asp. fumigatus, Asp. niger, Candida albicans, Curvularia sp., Diplosporium sp., Drechslera sp., Fusarium sp., Hormodendrum sp., Mucor sp., Penicillium sp., Paecilomyces sp., Rhizopus sp., Rhodotorula sp., Syncephalastrum sp., Trichoderma sp. und Verticillium sp. wurden durch Konzentrationen von 0,5 bis 5,0 μg/ml von Natamycin gehemmt, 13 Pilze zeigten Hemmwirkung bei 10 μg/ml und alle auser Asp. flavus bei 100 μg/ml. Econazol, in einer Konzentration von 0,5 μg/ml, hemmte 7 Pilze vollstandig. Bei 7,5 μg/ml waren alle Pilze auser Rhodotorula gehemmt Konzentrationen bis zu 100 μg/ml hemmten schlieslich alle Pilze. Ketonazol zeigte einen ahnlichen Effekt nur bei 100 μg/ml, wahrend niedrigere Konzentrationen nur auf wenige Pilze wirkten. Am schwachsten war die Wirkung bei Amphotericin B, das bei 100 μg/ml nur Asp. niger, Drechslera, Altemaria, Curvularia und Paecilomyces henunte. Unter den weiterhin getesteten Chemikalien und Krau-tern waren Knoblauch (2,5 bis 50,0 μg/ml), Neem (1 %iger wassriger oder alkoholischer Nimbabaum-Extrakt) und Levamisol (0,1 bis 10 μg/ml) vollig ohne Wirkung. Das Dinatriumcitratsalz des Berberin zeigte eine ahnliche oder sogar bessere antimyzetische Wirkung als Berberinsulfat Gelbes Quecksilberoxyd war bei Konzentrationen von 2–10 μg/ml stark antimyzetisch wirksam und damit anderen, fruiher getesteten Chemikalien vergleichbar. Es besitzt auBerdem antibakterielle Wirkung bei Konzentrationen von 50 bis 200 μg/ml. Diese Ergebnisse liesen sich in wiederholten Experimenten bestatigen." @default.
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• W2008466251 date "2009-04-24" @default.
• W2008466251 modified "2023-09-27" @default.
• W2008466251 title "Further Studies on Antimycotic Agents/Weitere Untersuchungen über antimykotische Wirkstoffe" @default.
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• W2008466251 doi "https://doi.org/10.1111/j.1439-0507.1986.tb03811.x" @default.
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