Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008467857> ?p ?o ?g. }
- W2008467857 endingPage "11281" @default.
- W2008467857 startingPage "11272" @default.
- W2008467857 abstract "The 26S proteasome is the end point of the ubiquitin- and ATP-dependent degradation pathway. The 26S proteasome complex (26S PC) integrity and function has been shown to be highly dependent on ATP and its homolog nucleotides. We report here that the redox molecule NADH binds the 26S PC and is sufficient in maintaining 26S PC integrity even in the absence of ATP. Five of the 19S proteasome complex subunits contain a putative NADH binding motif (GxGxxG) including the AAA-ATPase subunit, Psmc1 (Rpt2). We demonstrate that recombinant Psmc1 binds NADH via the GxGxxG motif. Introducing the ΔGxGxxG Psmc1 mutant into cells results in reduced NADH-stabilized 26S proteasomes and decreased viability following redox stress induced by the mitochondrial inhibitor rotenone. The newly identified NADH binding of 26S proteasomes advances our understanding of the molecular mechanisms of protein degradation and highlights a new link between protein homeostasis and the cellular metabolic/redox state." @default.
- W2008467857 created "2016-06-24" @default.
- W2008467857 creator A5004108571 @default.
- W2008467857 creator A5019953572 @default.
- W2008467857 creator A5027786131 @default.
- W2008467857 creator A5044519489 @default.
- W2008467857 creator A5059236444 @default.
- W2008467857 creator A5071233555 @default.
- W2008467857 creator A5078552361 @default.
- W2008467857 creator A5086709693 @default.
- W2008467857 date "2014-04-01" @default.
- W2008467857 modified "2023-10-13" @default.
- W2008467857 title "NADH Binds and Stabilizes the 26S Proteasomes Independent of ATP" @default.
- W2008467857 cites W1518640128 @default.
- W2008467857 cites W1586233686 @default.
- W2008467857 cites W1665675901 @default.
- W2008467857 cites W1756233575 @default.
- W2008467857 cites W1971841367 @default.
- W2008467857 cites W1973668650 @default.
- W2008467857 cites W1980615331 @default.
- W2008467857 cites W1987738803 @default.
- W2008467857 cites W1991930087 @default.
- W2008467857 cites W1992174702 @default.
- W2008467857 cites W1993652875 @default.
- W2008467857 cites W2005449470 @default.
- W2008467857 cites W2007050986 @default.
- W2008467857 cites W2016151751 @default.
- W2008467857 cites W2018228226 @default.
- W2008467857 cites W2025043912 @default.
- W2008467857 cites W2030777235 @default.
- W2008467857 cites W2032421019 @default.
- W2008467857 cites W2035503828 @default.
- W2008467857 cites W2045442669 @default.
- W2008467857 cites W2046366527 @default.
- W2008467857 cites W2046937344 @default.
- W2008467857 cites W2046938310 @default.
- W2008467857 cites W2047109055 @default.
- W2008467857 cites W2053359084 @default.
- W2008467857 cites W2063041018 @default.
- W2008467857 cites W2068134926 @default.
- W2008467857 cites W2090829119 @default.
- W2008467857 cites W2099952208 @default.
- W2008467857 cites W2100498403 @default.
- W2008467857 cites W2107613496 @default.
- W2008467857 cites W2108812570 @default.
- W2008467857 cites W2116724545 @default.
- W2008467857 cites W2142045367 @default.
- W2008467857 cites W2152424535 @default.
- W2008467857 cites W2156791826 @default.
- W2008467857 cites W2158714788 @default.
- W2008467857 cites W2169809267 @default.
- W2008467857 cites W2171213306 @default.
- W2008467857 cites W2178503716 @default.
- W2008467857 doi "https://doi.org/10.1074/jbc.m113.537175" @default.
- W2008467857 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4036265" @default.
- W2008467857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24596095" @default.
- W2008467857 hasPublicationYear "2014" @default.
- W2008467857 type Work @default.
- W2008467857 sameAs 2008467857 @default.
- W2008467857 citedByCount "35" @default.
- W2008467857 countsByYear W20084678572014 @default.
- W2008467857 countsByYear W20084678572015 @default.
- W2008467857 countsByYear W20084678572016 @default.
- W2008467857 countsByYear W20084678572017 @default.
- W2008467857 countsByYear W20084678572018 @default.
- W2008467857 countsByYear W20084678572019 @default.
- W2008467857 countsByYear W20084678572020 @default.
- W2008467857 countsByYear W20084678572021 @default.
- W2008467857 countsByYear W20084678572022 @default.
- W2008467857 countsByYear W20084678572023 @default.
- W2008467857 crossrefType "journal-article" @default.
- W2008467857 hasAuthorship W2008467857A5004108571 @default.
- W2008467857 hasAuthorship W2008467857A5019953572 @default.
- W2008467857 hasAuthorship W2008467857A5027786131 @default.
- W2008467857 hasAuthorship W2008467857A5044519489 @default.
- W2008467857 hasAuthorship W2008467857A5059236444 @default.
- W2008467857 hasAuthorship W2008467857A5071233555 @default.
- W2008467857 hasAuthorship W2008467857A5078552361 @default.
- W2008467857 hasAuthorship W2008467857A5086709693 @default.
- W2008467857 hasBestOaLocation W20084678571 @default.
- W2008467857 hasConcept C104292427 @default.
- W2008467857 hasConcept C104317684 @default.
- W2008467857 hasConcept C185592680 @default.
- W2008467857 hasConcept C25602115 @default.
- W2008467857 hasConcept C27740335 @default.
- W2008467857 hasConcept C2779564974 @default.
- W2008467857 hasConcept C28859421 @default.
- W2008467857 hasConcept C512185932 @default.
- W2008467857 hasConcept C55493867 @default.
- W2008467857 hasConcept C86803240 @default.
- W2008467857 hasConcept C95444343 @default.
- W2008467857 hasConceptScore W2008467857C104292427 @default.
- W2008467857 hasConceptScore W2008467857C104317684 @default.
- W2008467857 hasConceptScore W2008467857C185592680 @default.
- W2008467857 hasConceptScore W2008467857C25602115 @default.
- W2008467857 hasConceptScore W2008467857C27740335 @default.
- W2008467857 hasConceptScore W2008467857C2779564974 @default.
- W2008467857 hasConceptScore W2008467857C28859421 @default.