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• W2008468534 abstract "p38α MAP kinase is a key anti-inflammatory target for rheumatoid arthritis, influencing biosynthesis of pro-inflammatory cytokines TNFα and IL-1β at a translational and transcriptional level. In this paper, we describe how we have optimized a series of novel p38α/β inhibitors using crystal structures of our inhibitors bound to p38α, classical medicinal chemistry, and modeling of virtual libraries to derive a molecule suitable for progression into clinical development." @default.
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• W2008468534 date "2009-09-22" @default.
• W2008468534 modified "2023-09-26" @default.
• W2008468534 title "p38α Mitogen-Activated Protein Kinase Inhibitors: Optimization of a Series of Biphenylamides to Give a Molecule Suitable for Clinical Progression" @default.
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• W2008468534 doi "https://doi.org/10.1021/jm9004779" @default.
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