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• W2008471657 abstract "We set out to identify whether HOCl, which is generated from H2O2 /MPO/Cl−, is a proximal mediator of H2O2 programmed cell death in the HL-60 human leukemia cell. We found that authentic HOCl induces apoptosis in the HL-60 cell. Both the addition of methionine, an HOCl scavenger, and the removal of Cl− from the medium to prevent the formation of HOCl inhibited H2O2-induced apoptosis. HL-60 cells underwent apoptosis when exposed to HOCl in full medium, which gives rise to chloramines by the reaction of HOCl with amine groups, but not by HOCl in the amine-free HBSS, in which HOCl but not chloramines can be detected. Authentic chloramines induced apoptosis in this cell line in a concentration-dependent manner and at concentrations lower than HOCl. Full medium exposed to HOCl for 24 h would support methionine noninhibitable apoptosis, but did not react with 2-nitro-5-thiobenzoic acid (TNB), raising the possibility that the final inducer is a nonoxidant formed from HOCl and chloramines. We conclude that the signal for apoptosis induced by H2O2 in the MPO-containing HL-60 cell involves the reaction of the diffusible oxidant HOCl with amines producing chloramines and a subsequent non-TNB-reactive product." @default.
• W2008471657 created "2016-06-24" @default.
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• W2008471657 date "2002-05-01" @default.
• W2008471657 modified "2023-10-17" @default.
• W2008471657 title "Hydrogen peroxide-induced apoptosis of HL-60 human leukemia cells is mediated by the oxidants hypochlorous acid and chloramines" @default.
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• W2008471657 doi "https://doi.org/10.1016/s0003-9861(02)00053-x" @default.
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