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• W2008473913 abstract "Inhaled NO improves oxygenation and decreases ECMO use in term newborns with PPHN. From the available information, a reasonable recommendation for a starting dose of iNO in the term infant is 20 ppm, with reductions in dose over time. Toxicity isapparent at 80 ppm, causing increases in methemoglobinemia and inspired ni trogen dioxide. High doses (<20 ppm) of iNO may also prolong bleeding time, but clinically significant increases in bleeding complications have not been reported in term newborns. The use of iNO in non-ECMO centers must be done cautiously, with arrange ments in place for transport to an ECMO center without interruption of iNO delivery in patients with suboptimal immediate responses. Finally, there is increasing evidence for the potential role of low-dose iNO (5 ppm) in premature newborns with hypoxemic respiratory failure. Low-dose iNO causes immediate improvement in oxygenation and may prove to be useful as a lung-specific anti-inflammatory therapy. However, clinical application should currently be limited to controlled trials that target outcomes of both safety and efficacy. Inhaled NO improves oxygenation and decreases ECMO use in term newborns with PPHN. From the available information, a reasonable recommendation for a starting dose of iNO in the term infant is 20 ppm, with reductions in dose over time. Toxicity isapparent at 80 ppm, causing increases in methemoglobinemia and inspired ni trogen dioxide. High doses (<20 ppm) of iNO may also prolong bleeding time, but clinically significant increases in bleeding complications have not been reported in term newborns. The use of iNO in non-ECMO centers must be done cautiously, with arrange ments in place for transport to an ECMO center without interruption of iNO delivery in patients with suboptimal immediate responses. Finally, there is increasing evidence for the potential role of low-dose iNO (5 ppm) in premature newborns with hypoxemic respiratory failure. Low-dose iNO causes immediate improvement in oxygenation and may prove to be useful as a lung-specific anti-inflammatory therapy. However, clinical application should currently be limited to controlled trials that target outcomes of both safety and efficacy." @default.
• W2008473913 created "2016-06-24" @default.
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• W2008473913 date "2000-06-01" @default.
• W2008473913 modified "2023-10-16" @default.
• W2008473913 title "Clinical approach to inhaled nitric oxide therapy in newborn with hypoxemia" @default.
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• W2008473913 doi "https://doi.org/10.1016/s0022-3476(00)10660-2" @default.
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