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- W2008478586 abstract "MAP1B is a major microtubule-associated phospho-protein in growing axons and growth cones. Recent findings suggest that glycogen synthase kinase 3beta (GSK-3beta) phosphorylation of MAP1B may act as a molecular switch to regulate microtubule stability during axonogenesis. The effects of lithium, an inhibitor of GSK-3beta, on neurons in culture, are consistent with this suggestion. However, lithium is not a specific inhibitor of GSK-3beta. In the experiments reported here we have compared the effects of lithium with SB-216763, a new, potent and specific inhibitor of GSK-3 that has a different mechanism of action from lithium. We examined the effects of inhibition of GSK-3beta on axonogenesis, microtubule distribution, and growth cone behavior in cultured embryonic chick primary sensory neurons. Both compounds reduced axon elongation rates and increased growth cone size. In addition, both compounds slowed growth cone filopodia dynamics. These behavioral changes correlated with a decrease in MAP1B phosphorylation and an increase in the number of stable microtubules in growth cones. These results suggest that a major role of MAP1B in growing axons and growth cones is to regulate microtubule and actin filament stability. Furthermore, this function is regulated by phosphorylation of MAP1B by GSK-3beta." @default.
- W2008478586 created "2016-06-24" @default.
- W2008478586 creator A5063449990 @default.
- W2008478586 creator A5078962442 @default.
- W2008478586 date "2003-08-01" @default.
- W2008478586 modified "2023-10-18" @default.
- W2008478586 title "Inhibition of glycogen synthase kinase 3β in sensory neurons in culture alters filopodia dynamics and microtubule distribution in growth cones" @default.
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- W2008478586 doi "https://doi.org/10.1016/s1044-7431(03)00095-2" @default.
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