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• W2008483071 abstract "The objective of this retrospective study was to present long-term follow-up data for 110 consecutive children and young adults treated for a benign cerebellar astrocytoma at our institution between 1960 and 2001. Mean age at presentation was 8.9 years. The total surgical mortality was 9%, but declined from 16% in 1960–1977 to 0% in 1988–2001. At the close of the study 97/110 patients were still alive. Nine deaths were surgery related, 2 patients died of shunt-related causes and 2 patients died due to tumor recurrence. Five-, 10- and 25-year survival were 90, 89 and 85%, respectively. Multiple Cox regression analysis showed that tumor infiltration of the brain stem and the time period of surgery were the only explanatory variables significantly associated with survival. Five-year survival improved from 79% in the time period of 1960–1977 to 100% in the time period of 1988–2001. Tumor recurrence after total tumor resection was observed in 5 of 76 (7%) evaluable patients. Growth of residual tumor after subtotal tumor resection was observed in 7 of 26 (27%) evaluable patients. Recent follow- up MR revealed regression of residual tumor in 14 of 16 patients. Only 5 of these patients had received radiotherapy. Thus, spontaneous regression of residual tumor is a more frequent event than growth of residual tumor. The functional outcome was favorable in 82% of the patients [Karnofsky performance index (KPI) ≧90]. Eighteen percent of the patients had moderate to severe disabilities (KPI 50–80). <i>Conclusions:</i> Benign cerebellar astrocytoma is a surgical disease where the prognosis with respect to both survival and functional outcome is favorable. Spontaneous regression of residual tumor is frequently encountered, allowing for observation of residual tumors instead of performing a second resection in cases where a second resection carries a high risk of neurological sequelae." @default.
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• W2008483071 date "2002-01-01" @default.
• W2008483071 modified "2023-10-16" @default.
• W2008483071 title "Long-Term Outcome after Resection of Benign Cerebellar Astrocytomas in Children and Young Adults (0–19 Years): Report of 110 Consecutive Cases" @default.
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• W2008483071 doi "https://doi.org/10.1159/000065108" @default.
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