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- W2008492770 abstract "ABSTRACT Immunohistochemical localization of 17α-hydroxylase/C17-20 lyase (P-450 17α,lyase ) and aromatase cytochrome P-450 (P-450 arom ) in polycystic ovary (PCO) syndrome was studied using specific polyclonal antibodies which had been raised against the corresponding enzymes. In the majority of follicles that were atretic and smaller than 7 mm in diameter, theca interna cells showed high P-450 17α,lyase immunoreaction, while small numbers of granulosa cells showed little P-450 arom immunoreaction. In some atretic follicles that were larger than 11 mm in diameter, the hyperplastic theca interna cell layer showed high immunoreaction to P-450 17α,lyase , while the poorly proliferated granulosa cell layer showed a mixture of weak and negative immunoreaction to P-450 arom . No immunoreaction to P-450 17α,lyase or P-450 arom was recognized in PCO stroma. These findings suggest that the theca interna cells and the granulosa cells from PCOs show abnormal steroidogenic function, while the localization of P-450 17α,lyase and P-450 arom in PCOs was essentially identical to that in the normal ovary. Theca interna cells in PCO atretic follicles are the main site of excess androgen production. Journal of Endocrinology (1993) 139, 503–509" @default.
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- W2008492770 title "Immunohistochemical localization of 17α-hydroxylase/C17-20 lyase and aromatase cytochrome P-450 in polycystic human ovaries" @default.
- W2008492770 doi "https://doi.org/10.1677/joe.0.1390503" @default.
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