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- W2008494805 abstract "N alpha-9-Fluorenylmethyloxycarbonyl (Fmoc) amino acids will be of advantage in solid phase peptide synthesis. The Fmoc-group is quantitatively cleaved by mild base (piperidine). This permits the use of tert-butyl-type side chain blocking and of peptide-to-resin linkage cleavable by mild acidolysis. Side reactions arising from repetitive acid deprotection and final HF cleavage in contemporary solid phase synthesis are avoided. Fully bioactive and homogeneous dihydrosomatostatin was obtained in 53% overall yield." @default.
- W2008494805 created "2016-06-24" @default.
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- W2008494805 date "2009-01-12" @default.
- W2008494805 modified "2023-10-01" @default.
- W2008494805 title "SOLID-PHASE PEPTIDE SYNTHESIS USING MILD BASE CLEAVAGE OF NαFLUORENYLMETHYLOXYCARBONYLAMINO ACIDS, EXEMPLIFIED BY A SYNTHESIS OF DIHYDROSOMATOSTATIN" @default.
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- W2008494805 doi "https://doi.org/10.1111/j.1399-3011.1978.tb02845.x" @default.
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