FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008499054> ?p ?o ?g. }

• W2008499054 endingPage "1425" @default.
• W2008499054 startingPage "1421" @default.
• W2008499054 abstract "Surgical stress and anesthesia cause immunosuppression that may predispose patients to postoperative infections.T helper lymphocytes play a major role in the immune response by controlling cell-mediated and humoral immunity. The type of immune response generated is determined by the differentiation of precursor T helper cells into Th1 or Th2 cells. Each cell subset secretes a particular array of cytokines that further augment the differentiation into that subset. Th1 cells produce interferon gamma and are responsible for cell-mediated immunity. Th2 cells produce interleukin-4 and are more effective in inducing humoral immunity. Cytokine concentrations are altered during surgery and anesthesia, which may effect Th cell predominance and, therefore, subsequent immune responses. We determined Th1 to Th2 cell ratios in patients undergoing transurethral resection of the prostate (TURP) using either spinal or general anesthesia. Mononuclear cells were isolated before anesthesia, immediately after surgery, and after 24 h from patients undergoing TURP, 10 under general anesthesia and 9 under spinal anesthesia. T helper cell subsets were quantified by using flow cytometry, and the ratio of Th1 to Th2 cells was calculated. Th1 to Th2 ratios in patients receiving spinal anesthesia increased over the three time points studied (P = 0.029) but did not change in patients who had general anesthesia (P = 0.11). At 24 h, Th1 to Th2 ratios were significantly higher in the spinal group than in patients who received general anesthesia (P = 0.0157). Total T helper cell numbers remained constant. These data suggest that, from an immunological viewpoint, spinal anesthesia, but not general anesthesia, benefits the patient by maintaining Th1 cell numbers, thereby promoting cellular immunity. Implications: Spinal anesthesia may result in less immunosuppression after surgery. We found that the ratio of T helper 1 to T helper 2 cells was higher in patients undergoing prostate surgery by spinal rather than general anesthesia. Th1 cells promote protective immune responses that may result in fewer postoperative infections. (Anesth Analg 1998;87:1421-5)" @default.
• W2008499054 created "2016-06-24" @default.
• W2008499054 creator A5003279536 @default.
• W2008499054 creator A5054932314 @default.
• W2008499054 creator A5077086051 @default.
• W2008499054 date "1998-12-01" @default.
• W2008499054 modified "2023-10-14" @default.
• W2008499054 title "Spinal but Not General Anesthesia Increases the Ratio of T Helper 1 to T Helper 2 Cell Subsets in Patients Undergoing Transurethral Resection of the Prostate" @default.
• W2008499054 cites W1556342164 @default.
• W2008499054 cites W1829148295 @default.
• W2008499054 cites W1982954026 @default.
• W2008499054 cites W1986629773 @default.
• W2008499054 cites W1992231572 @default.
• W2008499054 cites W1996505971 @default.
• W2008499054 cites W2015156937 @default.
• W2008499054 cites W2020487781 @default.
• W2008499054 cites W2039911822 @default.
• W2008499054 cites W2056796152 @default.
• W2008499054 cites W2070696234 @default.
• W2008499054 cites W2082649398 @default.
• W2008499054 cites W2084815047 @default.
• W2008499054 cites W2086858064 @default.
• W2008499054 cites W2088713651 @default.
• W2008499054 cites W2091727873 @default.
• W2008499054 cites W2108668542 @default.
• W2008499054 cites W2113879726 @default.
• W2008499054 cites W2115934277 @default.
• W2008499054 cites W2121020567 @default.
• W2008499054 cites W2139360765 @default.
• W2008499054 cites W2141247412 @default.
• W2008499054 cites W2153639301 @default.
• W2008499054 cites W2154826391 @default.
• W2008499054 cites W2154928622 @default.
• W2008499054 cites W2164922460 @default.
• W2008499054 cites W2171499071 @default.
• W2008499054 cites W2172466148 @default.
• W2008499054 doi "https://doi.org/10.1097/00000539-199812000-00041" @default.
• W2008499054 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9842841" @default.
• W2008499054 hasPublicationYear "1998" @default.
• W2008499054 type Work @default.
• W2008499054 sameAs 2008499054 @default.
• W2008499054 citedByCount "33" @default.
• W2008499054 countsByYear W20084990542012 @default.
• W2008499054 countsByYear W20084990542014 @default.
• W2008499054 countsByYear W20084990542015 @default.
• W2008499054 countsByYear W20084990542016 @default.
• W2008499054 countsByYear W20084990542017 @default.
• W2008499054 countsByYear W20084990542018 @default.
• W2008499054 countsByYear W20084990542019 @default.
• W2008499054 crossrefType "journal-article" @default.
• W2008499054 hasAuthorship W2008499054A5003279536 @default.
• W2008499054 hasAuthorship W2008499054A5054932314 @default.
• W2008499054 hasAuthorship W2008499054A5077086051 @default.
• W2008499054 hasConcept C121608353 @default.
• W2008499054 hasConcept C126322002 @default.
• W2008499054 hasConcept C137061746 @default.
• W2008499054 hasConcept C1491633281 @default.
• W2008499054 hasConcept C202751555 @default.
• W2008499054 hasConcept C203014093 @default.
• W2008499054 hasConcept C2776090121 @default.
• W2008499054 hasConcept C2776235491 @default.
• W2008499054 hasConcept C2778690821 @default.
• W2008499054 hasConcept C2779341262 @default.
• W2008499054 hasConcept C2780768273 @default.
• W2008499054 hasConcept C2781136212 @default.
• W2008499054 hasConcept C3017875465 @default.
• W2008499054 hasConcept C42219234 @default.
• W2008499054 hasConcept C54355233 @default.
• W2008499054 hasConcept C553184892 @default.
• W2008499054 hasConcept C55493867 @default.
• W2008499054 hasConcept C71924100 @default.
• W2008499054 hasConcept C86803240 @default.
• W2008499054 hasConcept C8891405 @default.
• W2008499054 hasConceptScore W2008499054C121608353 @default.
• W2008499054 hasConceptScore W2008499054C126322002 @default.
• W2008499054 hasConceptScore W2008499054C137061746 @default.
• W2008499054 hasConceptScore W2008499054C1491633281 @default.
• W2008499054 hasConceptScore W2008499054C202751555 @default.
• W2008499054 hasConceptScore W2008499054C203014093 @default.
• W2008499054 hasConceptScore W2008499054C2776090121 @default.
• W2008499054 hasConceptScore W2008499054C2776235491 @default.
• W2008499054 hasConceptScore W2008499054C2778690821 @default.
• W2008499054 hasConceptScore W2008499054C2779341262 @default.
• W2008499054 hasConceptScore W2008499054C2780768273 @default.
• W2008499054 hasConceptScore W2008499054C2781136212 @default.
• W2008499054 hasConceptScore W2008499054C3017875465 @default.
• W2008499054 hasConceptScore W2008499054C42219234 @default.
• W2008499054 hasConceptScore W2008499054C54355233 @default.
• W2008499054 hasConceptScore W2008499054C553184892 @default.
• W2008499054 hasConceptScore W2008499054C55493867 @default.
• W2008499054 hasConceptScore W2008499054C71924100 @default.
• W2008499054 hasConceptScore W2008499054C86803240 @default.
• W2008499054 hasConceptScore W2008499054C8891405 @default.
• W2008499054 hasIssue "6" @default.
• W2008499054 hasLocation W20084990541 @default.
• W2008499054 hasLocation W20084990542 @default.
• W2008499054 hasOpenAccess W2008499054 @default.
• W2008499054 hasPrimaryLocation W20084990541 @default.

• next