FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008499078> ?p ?o ?g. }

• W2008499078 endingPage "670" @default.
• W2008499078 startingPage "657" @default.
• W2008499078 abstract "Abstract Toxicogenomics has the potential to elucidate gene–environment interactions to identify genes that are affected by a particular chemical at the early stages of the toxicological response and to establish parallelisms between different organisms. The fungicide mancozeb, widely used in agriculture, is an ethylene‐bis‐dithiocarbamate complex with manganese and zinc. Exposure to this pesticide has been linked to the development of idiopathic Parkinson's disease and cancer. Given that many signalling pathways and their molecular components are substantially conserved among eukaryotic organisms, we used Saccharomyces cerevisiae to get insights into the molecular mechanisms of mancozeb toxicity and adaptation based on expression proteomics. The early global response to mancozeb was analysed by quantitative proteomics using 2‐DE. The target genes ( e.g . TSA1 , TSA2 , SOD1 , SOD2 , AHP1 , GRE2 , GRX1 , CYS3 , PRE3 , PRE6 , PRE8 , PRE9 , EFT1 , RPS5 , TIF11 , HSP31 , HSP26 , HSP104 , HSP60 , HSP70 ‐family) and the putative main transcription activators ( e.g . Yap1, Msn2/Msn4, Met4, Hsf1, Aft1, Pdr1, Skn7, Rpn4p, Gcn4) of the complex mancozeb‐induced expression changes are related with yeast response to stress, in particular to oxidative stress, protein translation initiation and protein folding, disassembling of protein aggregates and degradation of damaged proteins. Our results also suggest that this study provided powerful indications that may be useful to expand the knowledge obtained in yeast not only to the global response to mancozeb toxicity in phytopathogenic fungi but also to humans." @default.
• W2008499078 created "2016-06-24" @default.
• W2008499078 creator A5011114213 @default.
• W2008499078 creator A5049463180 @default.
• W2008499078 creator A5072239287 @default.
• W2008499078 date "2009-01-29" @default.
• W2008499078 modified "2023-09-30" @default.
• W2008499078 title "Insights into yeast adaptive response to the agricultural fungicide mancozeb: A toxicoproteomics approach" @default.
• W2008499078 cites W1517316106 @default.
• W2008499078 cites W1964742940 @default.
• W2008499078 cites W1970679073 @default.
• W2008499078 cites W1971389338 @default.
• W2008499078 cites W1975402369 @default.
• W2008499078 cites W1976544696 @default.
• W2008499078 cites W1979959779 @default.
• W2008499078 cites W1981384832 @default.
• W2008499078 cites W1981593008 @default.
• W2008499078 cites W1990987722 @default.
• W2008499078 cites W1991162461 @default.
• W2008499078 cites W1991366673 @default.
• W2008499078 cites W1999469282 @default.
• W2008499078 cites W2001340083 @default.
• W2008499078 cites W2006007524 @default.
• W2008499078 cites W2008847964 @default.
• W2008499078 cites W2012032995 @default.
• W2008499078 cites W2013453206 @default.
• W2008499078 cites W2013803609 @default.
• W2008499078 cites W2019533087 @default.
• W2008499078 cites W2020310293 @default.
• W2008499078 cites W2021620432 @default.
• W2008499078 cites W2025905237 @default.
• W2008499078 cites W2028451714 @default.
• W2008499078 cites W2031477835 @default.
• W2008499078 cites W2032392662 @default.
• W2008499078 cites W2035672439 @default.
• W2008499078 cites W2035876392 @default.
• W2008499078 cites W2036425854 @default.
• W2008499078 cites W2036890934 @default.
• W2008499078 cites W2038931212 @default.
• W2008499078 cites W2039712191 @default.
• W2008499078 cites W2045800514 @default.
• W2008499078 cites W2046385725 @default.
• W2008499078 cites W2054236618 @default.
• W2008499078 cites W2059522016 @default.
• W2008499078 cites W2065109317 @default.
• W2008499078 cites W2065462657 @default.
• W2008499078 cites W2071995179 @default.
• W2008499078 cites W2075943484 @default.
• W2008499078 cites W2079112405 @default.
• W2008499078 cites W2081400315 @default.
• W2008499078 cites W2083676758 @default.
• W2008499078 cites W2088228878 @default.
• W2008499078 cites W2095185893 @default.
• W2008499078 cites W2109535551 @default.
• W2008499078 cites W2111129974 @default.
• W2008499078 cites W2111748628 @default.
• W2008499078 cites W2113486091 @default.
• W2008499078 cites W2118136186 @default.
• W2008499078 cites W2124904972 @default.
• W2008499078 cites W2129755489 @default.
• W2008499078 cites W2130792966 @default.
• W2008499078 cites W2131393988 @default.
• W2008499078 cites W2135718381 @default.
• W2008499078 cites W2135805255 @default.
• W2008499078 cites W2146671222 @default.
• W2008499078 cites W2147669401 @default.
• W2008499078 cites W2149064463 @default.
• W2008499078 cites W2150123812 @default.
• W2008499078 cites W2150401494 @default.
• W2008499078 cites W2160998060 @default.
• W2008499078 cites W2166185546 @default.
• W2008499078 cites W2175131107 @default.
• W2008499078 cites W4213226226 @default.
• W2008499078 cites W4247866908 @default.
• W2008499078 doi "https://doi.org/10.1002/pmic.200800452" @default.
• W2008499078 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19137554" @default.
• W2008499078 hasPublicationYear "2009" @default.
• W2008499078 type Work @default.
• W2008499078 sameAs 2008499078 @default.
• W2008499078 citedByCount "75" @default.
• W2008499078 countsByYear W20084990782012 @default.
• W2008499078 countsByYear W20084990782013 @default.
• W2008499078 countsByYear W20084990782014 @default.
• W2008499078 countsByYear W20084990782015 @default.
• W2008499078 countsByYear W20084990782016 @default.
• W2008499078 countsByYear W20084990782017 @default.
• W2008499078 countsByYear W20084990782018 @default.
• W2008499078 countsByYear W20084990782019 @default.
• W2008499078 countsByYear W20084990782020 @default.
• W2008499078 countsByYear W20084990782021 @default.
• W2008499078 countsByYear W20084990782022 @default.
• W2008499078 countsByYear W20084990782023 @default.
• W2008499078 crossrefType "journal-article" @default.
• W2008499078 hasAuthorship W2008499078A5011114213 @default.
• W2008499078 hasAuthorship W2008499078A5049463180 @default.
• W2008499078 hasAuthorship W2008499078A5072239287 @default.
• W2008499078 hasConcept C104317684 @default.
• W2008499078 hasConcept C150194340 @default.

• next